Saturday, May 31, 2014
1 “Time is an illusion. Lunchtime doubly so,” joked Douglas Adams in The Hitchhiker’s Guide to the Galaxy. Scientists aren’t laughing, though. Some speculative new physics theories suggest that time emerges from a more fundamental—and timeless—reality.
2 Try explaining that when you get to work late. The average U.S. city commuter loses 38 hours a year to traffic delays.
3 Wonder why you have to set your clock ahead in March?Daylight Saving Time began as a joke by Benjamin Franklin, who proposed waking people earlier on bright summer mornings so they might work more during the day and thus save candles. It was introduced in the U.K. in 1917 and then spread around the world.
4 Green days. The Department of Energy estimates that electricity demand drops by 0.5 percent during Daylight Saving Time, saving the equivalent of nearly 3 million barrels of oil.
5 By observing how quickly bank tellers made change, pedestrians walked, and postal clerks spoke, psychologists determined that the three fastest-paced U.S. cities are Boston, Buffalo, and New York.
6 The three slowest? Shreveport, Sacramento, and L.A.
7 One second used to be defined as 1/86,400 the length of a day. However, Earth’s rotation isn’t perfectly reliable. Tidal friction from the sun and moon slows our planet and increases the length of a day by 3 milliseconds per century.
8 This means that in the time of the dinosaurs, the day was just 23 hours long.
9 Weather also changes the day. During El Niño events, strong winds can slow Earth’s rotation by a fraction of a millisecond every 24 hours.
10 Modern technology can do better. In 1972 a network of atomic clocks in more than 50 countries was made the final authority on time, so accurate that it takes 31.7 million years to lose about one second.
11 To keep this time in sync with Earth’s slowing rotation, a “leap second” must be added every few years, most recently this past New Year’s Eve.
12 The world’s most accurate clock, at the National Institute of Standards and Technology in Colorado, measures vibrations of a single atom of mercury. In a billion years it will not lose one second.
13 Until the 1800s, every village lived in its own little time zone, with clocks synchronized to the local solar noon.
14 This caused havoc with the advent of trains and timetables. For a while watches were made that could tell both local time and “railway time.”
15 On November 18, 1883, American railway companies forced the national adoption of standardized time zones.
16 Thinking about how railway time required clocks in different places to be synchronized may have inspired Einstein to develop his theory of relativity, which unifies space and time.
17 Einstein showed that gravity makes time run more slowly. Thus airplane passengers, flying where Earth’s pull is weaker, age a few extra nanoseconds each flight.
18 According to quantum theory, the shortest moment of time that can exist is known as Planck time, or 0.0000000000000000000000000000000000000000001 second.
19 Time has not been around forever. Most scientists believe it was created along with the rest of the universe in the Big Bang, 13.7 billion years ago.
20 There may be an end of time. Three Spanish scientists posit that the observed acceleration of the expanding cosmos is an illusion caused by the slowing of time. According to their math, time may eventually stop, at which point everything will come to a standstill.
Thursday, May 22, 2014
Engineers build world's smallest, fastest nanomotor: Can fit inside a single cell
7:47:00 PM Science Lover
Researchers at the Cockrell School of Engineering at The University of Texas at Austin have built the smallest, fastest and longest-running tiny synthetic motor to date. The team's nanomotor is an important step toward developing miniature machines that could one day move through the body to administer insulin for diabetics when needed, or target and treat cancer cells without harming good cells.
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Simple nanomotor. Credit: Image courtesy of University of Texas at Austin
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With the goal of powering these yet-to-be invented devices, UT Austin engineers focused on building a reliable, ultra-high-speed nanomotor that can convert electrical energy into mechanical motion on a scale 500 times smaller than a grain of salt.
Mechanical engineering assistant professor Donglei "Emma" Fan led a team of researchers in the successful design, assembly and testing of a high-performing nanomotor in a nonbiological setting. The team's three-part nanomotor can rapidly mix and pump biochemicals and move through liquids, which is important for future applications. The team's study was published in a recent issue of Nature Communications.
Fan and her team are the first to achieve the extremely difficult goal of designing a nanomotor with large driving power.
With all its dimensions under 1 micrometer in size, the nanomotor could fit inside a human cell and is capable of rotating for 15 continuous hours at a speed of 18,000 RPMs, the speed of a motor in a jet airplane engine. Comparable nanomotors run significantly more slowly, from 14 RPMs to 500 RPMs, and have only rotated for a few seconds up to a few minutes.
Looking forward, nanomotors could advance the field of nanoelectromechanical systems (NEMS), an area focused on developing miniature machines that are more energy efficient and less expensive to produce. In the near future, the Cockrell School researchers believe their nanomotors could provide a new approach to controlled biochemical drug delivery to live cells.
To test its ability to release drugs, the researchers coated the nanomotor's surface with biochemicals and initiated spinning. They found that the faster the nanomotor rotated, the faster it released the drugs.
"We were able to establish and control the molecule release rate by mechanical rotation, which means our nanomotor is the first of its kind for controlling the release of drugs from the surface of nanoparticles," Fan said. "We believe it will help advance the study of drug delivery and cell-to-cell communications."
The researchers address two major issues for nanomotors so far: assembly and controls. The team built and operated the nanomotor using a patent-pending technique that Fan invented while studying at Johns Hopkins University. The technique relies on AC and DC electric fields to assemble the nanomotor's parts one by one.
In experiments, the researchers used the technique to turn the nanomotors on and off and propel the rotation either clockwise or counterclockwise. The researchers found that they could position the nanomotors in a pattern and move them in a synchronized fashion, which makes them more powerful and gives them more flexibility.
Fan and her team plan to develop new mechanical controls and chemical sensing that can be integrated into nanoelectromechanical devices. But first they plan to test their nanomotors near a live cell, which will allow Fan to measure how they deliver molecules in a controlled fashion.
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Sunday, April 20, 2014
Sugar-powered biobattery has 10 times the energy storage of lithium: Your smartphone might soon run on enzymes
7:33:00 PM Science Lover
As you probably know, from sucking down cans of Coke and masticating on candy, sugar — glucose, fructose, sucrose, dextrose — is an excellent source of energy. Biologically speaking, sugar molecules are energy-dense, easy to transport, and cheap to digest. There is a reason why almost every living cell on Earth generates its energy (ATP) from glucose. Now, researchers at Virginia Tech have successfully created a sugar-powered fuel cell that has an energy storage density of 596 amp-hours per kilo — or “one order of magnitude” higher than lithium-ion batteries. This fuel cell is refillable with a solution of maltodextrin, and its only by products are electricity and water. The chief researcher, Y.H. Percival Zhang, says the tech could be commercialized in as soon as three years.
Now, it’s not exactly news that sugar is an excellent energy source. As a culture we’ve probably known about it since before we were Homo sapiens. The problem is, unless you’re a living organism or some kind of incendiary device, extracting that energy is difficult. In nature, an enzymatic pathway is used — a production line of tailor-made enzymes that meddle with the glucose molecules until they become ATP. Because it’s easy enough to produce enzymes in large quantities, researchers have tried to create fuel cells that use artificial “metabolism” to break down glucose into electricity (biobatteries), but it has historically proven very hard to find the right pathway for maximum efficiency and to keep the enzymes in the right place over a long period of time.
Now, however, Zhang and friends at Virginia Tech appear to have built a high-density fuel cell that uses an enzymatic pathway to create a lot of electricity from glucose. There doesn’t seem to be much information on how stable this biobattery is over multiple refills, but if Zhang thinks it could be commercialized in three years, that’s a very good sign. Curiously, the research paper says that the enzymes are non-immobilized — meaning Zhang found a certain battery chemistry that doesn’t require the enzymes to be kept in place… or, alternatively, that it will only work for a very short time.
The Virginia Tech biobattery uses 13 enzymes, plus air (it’s an air-breathing biobattery), to produce nearly 24 electrons from a single glucose unit. This equates to a power output of 0.8 mW/cm, current density of 6 mA/cm, and energy storage density of 596 Ah/kg. This last figure is impressive, at roughly 10 times the energy density of the lithium-ion batteries in your mobile devices. [Research paper: doi:10.1038/ncomms4026 - "A high-energy-density sugar biobattery based on a synthetic enzymatic pathway"]
If Zhang’s biobatteries pan out, you might soon be recharging your smartphone by pouring in a solution of 15% maltodextrin. That battery would not only be very safe (it produces water and electricity), but very cheap to run and very green. This seems to fit in perfectly with Zhang’s homepage, which talks about how his main goals in life are replacing crude oil with sugar, and feeding the world.
The other area in which biobatteries might be useful is powering implanted devices, such as pacemakers — or, in the future, subcutaneous sensors and computers. Such a biobattery could feed on the glucose in your bloodstream, providing an endless supply of safe electricity for the myriad implants that futuristic technocrats will surely have.
Now, it’s not exactly news that sugar is an excellent energy source. As a culture we’ve probably known about it since before we were Homo sapiens. The problem is, unless you’re a living organism or some kind of incendiary device, extracting that energy is difficult. In nature, an enzymatic pathway is used — a production line of tailor-made enzymes that meddle with the glucose molecules until they become ATP. Because it’s easy enough to produce enzymes in large quantities, researchers have tried to create fuel cells that use artificial “metabolism” to break down glucose into electricity (biobatteries), but it has historically proven very hard to find the right pathway for maximum efficiency and to keep the enzymes in the right place over a long period of time.
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| A diagram of the enzymatic fuel cell. The little Pac-Man things are enzymes. |
The Virginia Tech biobattery uses 13 enzymes, plus air (it’s an air-breathing biobattery), to produce nearly 24 electrons from a single glucose unit. This equates to a power output of 0.8 mW/cm, current density of 6 mA/cm, and energy storage density of 596 Ah/kg. This last figure is impressive, at roughly 10 times the energy density of the lithium-ion batteries in your mobile devices. [Research paper: doi:10.1038/ncomms4026 - "A high-energy-density sugar biobattery based on a synthetic enzymatic pathway"]
If Zhang’s biobatteries pan out, you might soon be recharging your smartphone by pouring in a solution of 15% maltodextrin. That battery would not only be very safe (it produces water and electricity), but very cheap to run and very green. This seems to fit in perfectly with Zhang’s homepage, which talks about how his main goals in life are replacing crude oil with sugar, and feeding the world.
The other area in which biobatteries might be useful is powering implanted devices, such as pacemakers — or, in the future, subcutaneous sensors and computers. Such a biobattery could feed on the glucose in your bloodstream, providing an endless supply of safe electricity for the myriad implants that futuristic technocrats will surely have.
Wednesday, April 16, 2014
Lithium-sulfur batteries last longer with nanomaterial-packed cathode
8:49:00 PM Science Lover
Electric vehicles could travel farther and more renewable energy could be stored with lithium-sulfur batteries that use a unique powdery nanomaterial.
Researchers added the powder, a kind of nanomaterial called a metal organic framework, to the battery's cathode to capture problematic polysulfides that usually cause lithium-sulfur batteries to fail after a few charges. A paper describing the material and its performance was published online April 4 in the American Chemical Society journal Nano Letters."Lithium-sulfur batteries have the potential to power tomorrow's electric vehicles, but they need to last longer after each charge and be able to be repeatedly recharged," said materials chemist Jie Xiao of the Department of Energy's Pacific Northwest National Laboratory. "Our metal organic framework may offer a new way to make that happen."
Today's electric vehicles are typically powered by lithium-ion batteries. But the chemistry of lithium-ion batteries limits how much energy they can store. As a result, electric vehicle drivers are often anxious about how far they can go before needing to charge. One promising solution is the lithium-sulfur battery, which can hold as much as four times more energy per mass than lithium-ion batteries. This would enable electric vehicles to drive farther on a single charge, as well as help store more renewable energy. The down side of lithium-sulfur batteries, however, is they have a much shorter lifespan because they can't currently be charged as many times as lithium-ion batteries.
Energy Storage 101
The reason can be found in how batteries work. Most batteries have two electrodes: one is positively charged and called a cathode, while the second is negative and called an anode. Electricity is generated when electrons flow through a wire that connects the two. To control the electrons, positively charged atoms shuffle from one electrode to the other through another path: the electrolyte solution in which the electrodes sit.
The lithium-sulfur battery's main obstacles are unwanted side reactions that cut the battery's life short. The undesirable action starts on the battery's sulfur-containing cathode, which slowly disintegrates and forms molecules called polysulfides that dissolve into the liquid electrolyte. Some of the sulfur—an essential part of the battery's chemical reactions—never returns to the cathode. As a result, the cathode has less material to keep the reactions going and the battery quickly dies.
New materials for better batteries
Researchers worldwide are trying to improve materials for each battery component to increase the lifespan and mainstream use of lithium-sulfur batteries. For this research, Xiao and her colleagues honed in on the cathode to stop polysulfides from moving through the electrolyte.
Many materials with tiny holes have been examined to physically trap polysulfides inside the cathode. Metal organic frameworks are porous, but the added strength of PNNL's material is its ability to strongly attract the polysulfide molecules.
The framework's positively charged nickel center tightly binds the polysulfide molecules to the cathodes. The result is a coordinate covalent bond that, when combined with the framework's porous structure, causes the polysulfides to stay put.
"The MOF's highly porous structure is a plus that further holds the polysulfide tight and makes it stay within the cathode," said PNNL electrochemist Jianming Zheng.
Nanomaterial is key
Metal organic frameworks—also called MOFs—are crystal-like compounds made of metal clusters connected to organic molecules, or linkers. Together, the clusters and linkers assemble into porous 3-D structures. MOFs can contain a number of different elements. PNNL researchers chose the transition metal nickel as the central element for this particular MOF because of its strong ability to interact with sulfur.
During lab tests, a lithium-sulfur battery with PNNL's MOF cathode maintained 89 percent of its initial power capacity after 100 charge-and discharge cycles. Having shown the effectiveness of their MOF cathode, PNNL researchers now plan to further improve the cathode's mixture of materials so it can hold more energy. The team also needs to develop a larger prototype and test it for longer periods of time to evaluate the cathode's performance for real-world, large-scale applications.
PNNL is also using MOFs in energy-efficient adsorption chillers and to develop new catalysts to speed up chemical reactions.
"MOFs are probably best known for capturing gases such as carbon dioxide," Xiao said. "This study opens up lithium-sulfur batteries as a new and promising field for the nanomaterial."
This research was funded by the Department of Energy's Office of Energy Efficiency and Renewable Energy. Researchers analyzed chemical interactions on the MOF cathode with instruments at EMSL, DOE's Environmental Molecular Sciences Laboratory at PNNL.
In January, a Nature Communications paper by Xiao and some of her PNNL colleagues described another possible solution for lithium-sulfur batteries: developing a hybrid anode that uses a graphite shield to block polysulfides.
Source: http://phys.org/news/2014-04-lithium-sulfur-batteries-longer-nanomaterial-packed-cathode.html
Monday, March 31, 2014
Aging Successfully Reversed in Mice; Human Trials to Begin Next
7:41:00 PM Science Lover
Scientists have successfully reversed the aging process in mice according to a new study just released. Human trials are to begin next, possibly before the year is over. The study was published in the peer reviewed science journal Cell after researchers from both the U.S and Australia made the breakthrough discovery. Lead researcher David Sinclair of the University of New South Wales says he is hopeful that the outcome can be reproduced in human trials. A successful result in people would mean not just a slowing down of aging but a measurable reversal.
The study showed that after administering a certain compound to the mice, muscle degeneration and diseases caused by aging were reversed. Sinclair says the study results exceeded his expectations, explaining:
I’ve been studying aging at the molecular level now for nearly 20 years and I didn’t think I’d see a day when ageing could be reversed. I thought we’d be lucky to slow it down a little bit. The mice had more energy, their muscles were as though they’d be exercising and it was able to mimic the benefits of diet and exercise just within a week. We think that should be able to keep people healthier for longer and keep them from getting diseases of ageing.The compound the mice ate resulted in their muscles becoming very toned, as if they’d been exercising. Inflammation, a key factor in many disease processes, was drastically reduced. Insulin resistance also declined dramatically and the mice had much more energy overall. Researchers say that what happened to the mice could be compared to a 60 year old person suddenly having the muscle tone and energy of someone in his or her 20s.
What’s more, say the researchers, these stunning results were realized within just one week’s time. The compound raises the level of a naturally occurring substance in the human body called nicotinamide adenine dinucleotide. This substance decreases as people age, although those who follow a healthy diet and get plenty of exercise do not suffer the same level of reduction in the substance as do people who do not exercise. This may explain why people who remain fit into their senior years often enjoy better health than others.
Scientists who participated in the study say that poor communication between mitochondria and the cell nucleus is to blame for the aging process. The compound the researchers have developed cause the cells to be able to “talk” to each other again. They compared the relationship between the nucleus and the mitochondria to a married couple; by the time the couple has been married for 20 years, “communication breaks down” and they don’t talk to each other as much. Just like a marriage, this relationship and communication within it can be repaired, say the researchers.
Aging has successfully been reversed in mice, but Sinclair says he needs to raise more money before he can commit to a date when trials may begin in humans. The results of this initial study in mice are very promising and may pave the way for similar results in humans.
Sources: ABC News , Science Direct , Huffington Post
Friday, December 13, 2013
Instagram Direct messaging arrives to challenge Snapchat and Whatsapp
5:35:00 PM Science Lover
HIPSTER PHOTO SHARING SERVICE Instagram announced a messaging service called Instagram Direct on Thursday, as it looks to challenge Snapchat and Whatsapp.
Rumours surfaced at the end of November claiming that Instagram was plotting a messaging service to rival send-and-delete photo service Snapchat, and the firm put an end to the speculation on Thursday by announcing Instagram Direct.
The service does what it says on the tin, allowing Instagram users to send images and videos in direct messages to one another.
Instagram Direct lets users of the service send messages to up to 15 friends at once, much like Whatsapp, and allows groups to talk in real-time chats. Only people you follow can send you images and videos, Instagram said on Thursday, so you shouldn't have to worry about your inbox filling up with spam.
There's now an inbox logo on the top right hand corner of the app to access Instagram Direct, replacing the previous refresh button, which has been replaced with a pull to refresh function.
Instagram said, "There are moments in our lives that we want to share, but that will be the most relevant only to a smaller group of people - an inside joke between friends captured on the go, a special family moment or even just one more photo of your new puppy. Instagram Direct helps you share these moments.
"From how you capture photos and videos to the way you start conversations through likes and comments, we built Instagram Direct to feel natural to the Instagram experience you already know." Instagram Direct arrives in an update to the existing Instagram app, which is available to download for free from the iTunes App Store and Google Play store. The feature is not available yet for Windows Phone devices.
Rumours surfaced at the end of November claiming that Instagram was plotting a messaging service to rival send-and-delete photo service Snapchat, and the firm put an end to the speculation on Thursday by announcing Instagram Direct.
The service does what it says on the tin, allowing Instagram users to send images and videos in direct messages to one another.
Instagram Direct lets users of the service send messages to up to 15 friends at once, much like Whatsapp, and allows groups to talk in real-time chats. Only people you follow can send you images and videos, Instagram said on Thursday, so you shouldn't have to worry about your inbox filling up with spam.
There's now an inbox logo on the top right hand corner of the app to access Instagram Direct, replacing the previous refresh button, which has been replaced with a pull to refresh function.
Instagram said, "There are moments in our lives that we want to share, but that will be the most relevant only to a smaller group of people - an inside joke between friends captured on the go, a special family moment or even just one more photo of your new puppy. Instagram Direct helps you share these moments.
"From how you capture photos and videos to the way you start conversations through likes and comments, we built Instagram Direct to feel natural to the Instagram experience you already know." Instagram Direct arrives in an update to the existing Instagram app, which is available to download for free from the iTunes App Store and Google Play store. The feature is not available yet for Windows Phone devices.
Thursday, December 12, 2013
Bangkok designers draw attention for air-purifying bike idea
9:18:00 PM Science Lover
Some observers are calling it "the photosynthesis bike." The bike of interest is only a concept, not even a prototype yet, from designers in Bangkok. Nonetheless, in concept alone, it has captured a lot if imaginations, press coverage, and even picked up an award in the 2013 Red Dot competition for design concept. Dubbed "Air Purifier Bike," from Bangkok-based Lightfog Creative and Design, the bicycle presents a next-level functionality to bicycles as environmentally sound vehicles—to the point where the rider not only uses a clean mode of transport but also helps to purify the air along with the ride. (The Red Dot Award for design concept is part of a professional design competition for design concepts and prototypes worldwide.)
Silawat Virakul, Torsakul Kosaikul, and Suvaroj Poosrivongvanid are the designers behind the award-winning idea. They said their Air-Purifier Bike incorporates an air filter that screens dust and pollutants from the air, a photosynthesis system (including a water tank) that produces oxygen, an electric motor, and a battery. "While it is being ridden, air passes through the filter at the front of the bike, where it is cleaned before being released toward cyclist. The bike frame houses the photosynthesis system. When the bike is parked, the air-purifying functions can continue under battery power."According to a report on the bicycle and the designers behind it on the Fast Company Co.Exist site, the designers presently have mock-ups, but they have not yet built a prototype; they plan to build one soon.
"We want to design products which can reduce the air pollution in the city. So we decided to design a bike because we thought that bicycles are environmentally friendly vehicles for transportation," said creative director Silawat Virakul in an email to Co.Exist.
"Riding a bicycle can reduce traffic jam[s] in a city," said Virakul. "Moreover, we wanted to add more value to a bicycle by adding its ability to reduce the pollution."
If they were to advance their concept, they would be responding to many urban dwellers who are growing increasingly aware that bicycles ease pollution and are taking to bicycles for short-distance transportation. Earlier this year, Lucintel, a consulting and market research firm, analyzed the global bicycle industry in "Global Bicycle Industry 2013-2018: Trends, Profit, and Forecast Analysis." They noted that government initiatives to promote cycling to reduce carbon emissions and noise pollution are a strong growth driver. In addition, bicycles' energy efficiency, coupled with cycling as a fitness activity, will help propel demand during the forecast period.
Tuesday, October 15, 2013
New Device Harnesses Sun and Sewage to Produce Hydrogen Fuel
9:24:00 PM Science Lover
A novel device that uses only sunlight and wastewater to produce hydrogen gas could provide a sustainable energy source while improving the efficiency of wastewater treatment.
Either a PEC or MFC device can be used alone to produce hydrogen gas. Both, however, require a small additional voltage (an "external bias") to overcome the thermodynamic energy barrier for proton reduction into hydrogen gas. The need to incorporate an additional electric power element adds significantly to the cost and complication of these types of energy conversion devices, especially at large scales. In comparison, Li's hybrid solar-microbial device is self-driven and self-sustained, because the combined energy from the organic matter (harvested by the MFC) and sunlight (captured by the PEC) is sufficient to drive electrolysis of water.
In effect, the MFC component can be regarded as a self-sustained "bio-battery" that provides extra voltage and energy to the PEC for hydrogen gas generation. "The only energy sources are wastewater and sunlight," Li said. "The successful demonstration of such a self-biased, sustainable microbial device for hydrogen generation could provide a new solution that can simultaneously address the need for wastewater treatment and the increasing demand for clean energy."
Microbial fuel cells rely on unusual bacteria, known as electrogenic bacteria, that are able to generate electricity by transferring metabolically-generated electrons across their cell membranes to an external electrode. Li's group collaborated with researchers at Lawrence Livermore National Laboratory (LLNL) who have been studying electrogenic bacteria and working to enhance MFC performance. Initial "proof-of-concept" tests of the solar-microbial (PEC-MFC) device used a well-studied strain of electrogenic bacteria grown in the lab on artificial growth medium. Subsequent tests used untreated municipal wastewater from the Livermore Water Reclamation Plant. The wastewater contained both rich organic nutrients and a diverse mix of microbes that feed on those nutrients, including naturally occurring strains of electrogenic bacteria.
When fed with wastewater and illuminated in a solar simulator, the PEC-MFC device showed continuous production of hydrogen gas at an average rate of 0.05 m3/day, according to LLNL researcher and coauthor Fang Qian. At the same time, the turbid black wastewater became clearer. The soluble chemical oxygen demand--a measure of the amount of organic compounds in water, widely used as a water quality test--declined by 67 percent over 48 hours.
The researchers also noted that hydrogen generation declined over time as the bacteria used up the organic matter in the wastewater. Replenishment of the wastewater in each feeding cycle led to complete restoration of electric current generation and hydrogen gas production.
Qian said the researchers are optimistic about the commercial potential for their invention. Currently they are planning to scale up the small laboratory device to make a larger 40-liter prototype continuously fed with municipal wastewater. If results from the 40-liter prototype are promising, they will test the device on site at the wastewater treatment plant.
"The MFC will be integrated with the existing pipelines of the plant for continuous wastewater feeding, and the PEC will be set up outdoors to receive natural solar illumination," Qian said.
"Fortunately, the Golden State is blessed with abundant sunlight that can be used for the field test," Li added.
Qian and Hanyu Wang, a graduate student in Li's lab at UC Santa Cruz, are co-first authors of the ACS Nano paper. The other coauthors include UCSC graduate student Gongming Wang; LLNL researcher Yongqin Jiao; and Zhen He of Virginia Polytechnic Institute & State University. This research was supported by the National Science Foundation and Department of Energy.
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Tuesday, August 27, 2013
How the Brain Remembers Pleasure: Implications for Addiction
8:46:00 PM Science Lover
Key details of the way nerve cells in the brain remember pleasure are revealed in a study by University of Alabama at Birmingham (UAB) researchers published today in the journal Nature Neuroscience. The molecular events that form such "reward memories" appear to differ from those created by drug addiction, despite the popular theory that addiction hijacks normal reward pathways.
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| Brain activity (artist's rendering). (Credit: © James Steidl / Fotolia) |
This study in rats supports the idea that the mammalian brain features several memory types, each using different circuits, with memories accessed and integrated as needed. Ancient memory types include those that remind us what to fear, what to seek out (reward), how to move (motor memory) and navigate (place memory). More recent developments enable us to remember the year Columbus sailed and our wedding day.
"We believe reward memory may serve as a good model for understanding the molecular mechanisms behind many types of learning and memory," said David Sweatt, Ph.D., chair of the UAB Department of Neurobiology, director of the Evelyn F. McKnight Brain Institute at UAB and corresponding author for the study. "Our results provide a leap in the field's understanding of reward-learning mechanisms and promise to guide future attempts to solve related problems such as addiction and criminal behavior."
The study is the first to illustrate that reward memories are created by chemical changes that influence known memory-related genes in nerve cells within a brain region called the ventral tegmental area, or VTA. Experiments that blocked those chemical changes -- a mix of DNA methylation and demethylation -- in the VTA prevented rats from forming new reward memories.
Methylation is the attachment of a methyl group (one carbon and three hydrogens) to a DNA chain at certain spots (cytosine bases). When methylation occurs near a gene or inside a gene sequence, it generally is thought to turn the gene off and its removal is thought to turn the gene on. This back-and-forth change affects gene expression without changing the code we inherit from our parents. Operating outside the genetic machinery proper, epigenetic changes enable each cell type to do its unique job and to react to its environment.
Furthermore, a stem cell in the womb that becomes bone or liver cells must "remember" its specialized nature and pass that identity to its descendants as they divide and multiply to form organs. This process requires genetic memory, which largely is driven by methylation. Note, most nerve cells do not divide and multiply as do other cells. They can't, according to one theory, because they put their epigenetic mechanisms to work making actual memories.
Natural pleasure versus addiction
The brain's pleasure center is known to proceed through nerve cells that signal using the neurochemical dopamine and generally is located in the VTA. Dopaminergic neurons exhibit a "remarkable capacity" to pass on pleasure signals. Unfortunately, the evolutionary processes that attached pleasure to advantageous behaviors also accidentally reinforced bad ones.
Addiction to all four major classes of abused drugs -- psychostimulants, opiates, ethanol and nicotine -- has been linked to increased dopamine transmission in the same parts of the brain associated with normal reward processing. Cues that predict both normal reward and effects of cocaine or alcohol also make dopamine nerve cells fire as do the experiences they recall. That had led to idea that drug addiction must take over normal reward-memory nerve pathways.
Along those lines, past research has argued that dopamine-producing neurons in the VTA -- and in a region that receives downstream dopamine signals from the VTA called the nucleus accumbens (NAC) -- both were involved in natural reward and drug-addiction-based memory formation. While that may true to some extent, this study revealed that blocking methylation in the VTA with a drug stopped the ability of rats to attach rewarding experiences to remembered cues but doing so in the NAC did not.
"We observed an important distinction, not in circuitry, but instead in the epigenetic regulation of that circuitry between natural reward responses and those that occur downstream with drugs of abuse or psychiatric illness," said Jeremy Day, Ph.D., a post-doctoral scholar in Sweatt's lab and first author for this study. "Although drug experiences may co-opt normal reward mechanisms to some extent, our results suggest they also may engage entirely separate epigenetic mechanisms that contribute only to addiction and that may explain its strength."
To investigate the molecular and epigenetic changes in the VTA, researchers took their cue from 19th century Russian physiologist Ivan Pavlov, who was the first to study the phenomenon of conditioning. By ringing a bell each day before giving his dogs food, Pavlov soon found that the dogs would salivate at the sound of the bell.
In this study, rats were trained to associate a sound tone with the availability of sugar pellets in their feed ports. This same animal model has been used to make most discoveries about how human dopamine neurons work since the 1990s, and most approved drugs that affect the dopamine system (e.g. L-Dopa for Parkinson's) were tested in it before being cleared for human trials.
To separate the effects of memory-related brain changes from those arising from the pleasure of the eating itself, the rats were separated into three groups. Rats in the "CS+" rats got sugar pellets each time they heard a sound cue. The "CS-" group heard the sound the same number of times and received as many sugar pellets -- but never together. A third tone-only group heard the sounds but never received sugar rewards.
Rats that always received sugar with the sound cue were found to poke their feed ports with their noses at least twice as often during this cue as control rats after three, 25-sound-cue sessions. Nose pokes are an established measure of the degree to which a rat has come to associate a cue with the memory of a tasty treat.
The team found that those CS+ rats (sugar paired with sound) that were better at forming reward memories had significantly higher expression of the genes Egr1 and Fos than control rats These genes are known to regulate memory in other brain regions by fine-tuning the signaling capacity of the connections between nerve cells. In a series of experiments, the team next revealed the methylation and demethylation pattern that drove the changes in gene expression seen as memories formed.
The study demonstrated that reward-related experiences caused both types of DNA methylation known to regulate gene expression.
One type involves attaching methyl groups to pieces of DNA called promoters, which reside immediately upstream of individual gene sequences (between genes), that tell the machinery that follows genetic instructions to "start reading here." The attachment of a methyl group to a promoter generally interferes with this and silences a nearby gene. However, ancient organisms such as plants and insects have less methylation between their genes, and more of it within the coding regions of the genes themselves (within gene bodies). Such gene-body methylation has been shown to encourage rather than silence gene expression.
Specifically, the team reported that two sites in the promoter for Egr1 gene were demethylated during reward experiences and, to a greater degree, in rats that associated the sugar with the sound cue. Conversely, spots within the gene body of both Egr1 and Fos underwent methylation as reward memories formed.
"When designing therapeutic treatments for psychiatric illness, addictions or memory disorders, you must profoundly understand the function of the biological systems you're working with," Day said. "Our field has learned from experience that attempts to treat addiction with something that globally impairs normal reward perception or reward memories do not succeed. Our study suggests the possibility that future treatments could dial down drug addiction or mental illness without affecting normal rewards."
Along with Sweatt and Day, authors for the study were Daniel Childs, Mikael Guzman-Karlsson, Mercy Kibe, Jerome Moulden, Esther Song and Absar Tahir within the Department of Neurobiology and the Evelyn F. McKnight Brain Institute at University of Alabama at Birmingham. This work is supported by the National Institute on Drug Abuse (DA029419), the National Institute on Mental Health (MH091122 and MH057014), and the Evelyn F. McKnight Brain Research Foundation.
Friday, August 23, 2013
Researchers use mobile phones to measure happiness
10:01:00 AM Science Lover
Researchers at Princeton University are developing ways to use mobile phones to explore how one's environment influences one's sense of well-being.
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| Locations of study subjects on world map. Credit: Demography |
To conduct the study, the team created an application for the Android operating system that documented each person's location and periodically sent the question, "How happy are you?"
The investigators invited people to download the app, and over a three-week period, collected information from 270 volunteers in 13 countries who were asked to rate their happiness on a scale of 0 to 5. From the information collected, the researchers created and fine-tuned methods that could lead to a better understanding of how our environments influence emotional well-being. The study was published in the June issue of Demography.
The mobile phone method could help overcome some of the limitations that come with surveys conducted at people's homes, according to the researchers. Census measurements tie people to specific areas—the census tracts in which they live—that are usually not the only areas that people actually frequent.
"People spend a significant amount of time outside their census tracks," said John Palmer, a graduate student in the Woodrow Wilson School of Public and International Affairs and the paper's lead author. "If we want to get more precise findings of contextual measurements we need to use techniques like this."
Palmer teamed up with Thomas Espenshade, professor of sociology emeritus, and Frederic Bartumeus, a specialist in movement ecology at the Center for Advanced Studies of Blanes in Spain, along with Princeton's Chang Chung, a statistical programmer and data archivist in the Office of Population Research; Necati Ozgencil, a former Professional Specialist at Princeton; and Kathleen Li, who earned her undergraduate degree in computer science from Princeton in 2010, to design the free, open source application for the Android platform that would record participants' locations at various intervals based on either GPS satellites or cellular tower signals.
Though many of the volunteers lived in the United States, some were in Australia, Canada, China, France, Germany, Israel, Japan, Norway, South Korea, Spain, Sweden and the United Kingdom.
Palmer noted that the team's focus at this stage was not on generalizable conclusions about the link between environment and happiness, but rather on learning more about the mobile phone's capabilities for data collection. "I'd be hesitant to try to extend our substantive findings beyond those people who volunteered." he said.
However, the team did obtain some preliminary results regarding happiness: for example, male subjects tended to describe themselves as less happy when they were further from their homes, whereas females did not demonstrate a particular trend with regards to emotions and distance.
"One of the limitations of the study is that it is not representative of all people," Palmer said. Participants had to have smartphones and be Internet users. It is also possible that people who were happy were more likely to respond to the survey. However, Palmer said, the study demonstrates the potential for mobile phone research to reach groups of people that may be less accessible by paper surveys or interviews.
Palmer's doctoral dissertation will expand on this research, and his adviser Marta Tienda, the Maurice P. During Professor in Demographic Studies, said she was excited to see how it will impact the academic community. "His applied research promises to redefine how social scientists understand intergroup relations on many levels," she said.
This study involved contributions from the Center for Information Technology Policy at Princeton University, with institutional support from the National Institutes of Health Training Grant T32HD07163 and Infrastructure Grant R24HD047879.
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