Broken Genomes Behind Breast Cancers, Research Finds
The first detailed search of breast cancer genomes to uncover genomic rearrangements is published December 23. The team characterised the ways in which the human genome is broken and put back together in 24 cases of breast cancer.
Rearrangements involve reshuffling and reorganisation of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to which they are subject to genomic rearrangements: some are relatively undisturbed whereas others are fractured extensively and then reassembled with more than 200 rearrangements present.
Breast cancer cell. (Credit: Lorna McInroy, Wellcome Images)
Rearrangements involve reshuffling and reorganisation of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to which they are subject to genomic rearrangements: some are relatively undisturbed whereas others are fractured extensively and then reassembled with more than 200 rearrangements present.
