How the Japan Earthquake Shortened Days on Earth

How the Japan Earthquake Shortened Days on Earth

  10:14:00 AM    Science Lover

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The massive earthquake that struck northeast Japan Friday (March 11) has shortened the length Earth's day by a fraction and shifted how the planet's mass is distributed.

A new analysis of the 8.9-magnitude earthquake in Japan has found that the intense temblor has accelerated Earth's spin, shortening the length of the 24-hour day by 1.8 microseconds, according to geophysicist Richard Gross at NASA's Jet Propulsion Laboratory in Pasadena, Calif.

On March 11, 2011, at 2:46 p.m. local time (05:46 UTC), 
a magnitude 8.9 earthquake struck off the east coast of 
Japan. The epicenter was 80 miles (130 kilometers) east 
of Sendai, and 231 miles (373 km) northeast of Tokyo.If 
initial measurements are confirmed, it will be the world’s 

fifthlargest earthquake since 1900 and the worst in 

Japan's history.This image of Japan from 1999 was taken 

as part of SeaWiFS, the Sea-viewing Wide Field-of-view 

Sensor Project. CREDIT: NASA/Goddard Space 
Flight Center,SeaWiFSProject and ORBIMAGE

Gross refined his estimates of the Japan quake's impact – which previously suggested a 1.6-microsecond shortening of the day – based on new data on how much the fault that triggered the earthquake slipped to redistribute the planet's mass. A microsecond is a millionth of a second.

"By changing the distribution of the Earth's mass, the Japanese earthquake should have caused the Earth to rotate a bit faster, shortening the length of the day by about 1.8 microseconds," Gross told SPACE.com in an e-mail. More refinements are possible as new information on the earthquake comes to light, he added.

The scenario is similar to that of a figure skater drawing her arms inward during a spin to turn faster on the ice. The closer the mass shift during an earthquake is to the equator, the more it will speed up the spinning Earth.

One Earth day is about 24 hours, or 86,400 seconds, long. Over the course of a year, its length varies by about one millisecond, or 1,000 microseconds, due to seasonal variations in the planet's mass distribution such as the seasonal shift of the jet stream.

The initial data suggests Friday's earthquake moved Japan's main island about 8 feet, according to Kenneth Hudnut of the U.S. Geological Survey. The earthquake also shifted Earth's figure axis by about 6 1/2 inches (17 centimeters), Gross added.

The Earth's figure axis is not the same as its north-south axis in space, which it spins around once every day at a speed of about 1,000 mph (1,604 kph). The figure axis is the axis around which the Earth's mass is balanced and the north-south axis by about 33 feet (10 meters).

"This shift in the position of the figure axis will cause the Earth to wobble a bit differently as it rotates, but will not cause a shift of the Earth's axis in space – only external forces like the gravitational attraction of the sun, moon, and planets can do that," Gross said.

This isn't the first time a massive earthquake has changed the length of Earth's day. Major temblors have shortened day length in the past.

The 8.8-magnitude earthquake in Chile last year also sped up the planet's rotation and shortened the day by 1.26 microseconds. The 9.1 Sumatra earthquake in 2004 shortened the day by 6.8 microseconds.

And the impact from Japan's 8.9-magnitude temblor may not be completely over.The weaker aftershocks may contribute tiny changes to day length as well.

The March 11 quake was the largest ever recorded in Japan and is the world's fifth largest earthquake to strike since 1900, according to the USGS. It struck offshore about 231 miles (373 kilometers) northeast of Tokyo and 80 miles (130 km) east of the city of Sendai, and created a massive tsunami that has devastated Japan's northeastern coastal areas. At least 20 aftershocks registering a 6.0 magnitude or higher have followed the main temblor.

"In theory, anything that redistributes the Earth's mass will change the Earth's rotation," Gross said. "So in principle the smaller aftershocks will also have an effect on the Earth's rotation. But since the aftershocks are smaller their effect will also be smaller."

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Extra Prenatal Testosterone Makes a Genius?

Extra Prenatal Testosterone Makes a Genius?

  7:01:00 PM    Science Lover

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A longstanding debate as to whether genius is a byproduct of good genes or good environment has an upstart challenger that may take the discussion in an entirely new direction. University of Alberta researcher Marty Mrazik says being bright may be due to an excess level of a natural hormone.

A longstanding debate as to whether genius is a 
byproduct of good genes or good environment has an 
upstart challenger that may take the discussion in an 
entirely new direction. University of Alberta researcher 
Marty Mrazik says being bright may be due to an 
excess level of a natural hormone. 
(Credit: iStockphoto/Vasiliy Yakobchuk)

 

Mrazik, a professor in the Faculty of Education's educational psychology department, and a colleague from Rider University in the U.S., have published a paper in Roeper Review linking giftedness (having an IQ score of 130 or higher) to prenatal exposure of higher levels of testosterone. Mrazik hypothesizes that, in the same way that physical and cognitive deficiencies can be developed in utero, so, too, could similar exposure to this naturally occurring chemical result in giftedness.

"There seems to be some evidence that excessive prenatal exposure to testosterone facilitates increased connections in the brain, especially in the right prefrontal cortex," said Mrazik. "That's why we see some intellectually gifted people with distinct personality characteristics that you don't see in the normal population."

Mrazik's notion came from observations made during clinical assessments of gifted individuals. He and his fellow researcher observed some specific traits among the subjects. This finding stimulated a conversation on the role of early development in setting the foundation for giftedness.

"It gave us some interesting ideas that there could be more to this notion of genius being predetermined from a biological perspective than maybe people gave it credit for," said Mrazik. "It seemed that the bulk of evidence from new technologies (such as Functional MRI scans) tell us that there's a little bit more going on than a genetic versus environmental interaction."

Based on their observations, the researchers made the hypothesis that this hormonal "glitch" in the in-utero neurobiological development means that gifted children are born with an affinity for certain areas such as the arts, math or science. Mrazik cautions that more research is needed to determine what exact processes may cause the development of the gifted brain.

He notes that more is known about what derails the brain's normal development, thus charting what makes gifted people gifted is very much a new frontier. Mrazik hopes that devices such as the Functional MRI scanner will give them a deeper understanding of the role of neurobiology in the development of the gifted brain.

"It's really hard to say what does put the brain in a pathway where it's going to be much more precocious," he said. "The next steps in this research lay in finding out what exact stimuli causes this atypical brain development."

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New Switching Device Could Help Build an Ultrafast 'Quantum Internet'

New Switching Device Could Help Build an Ultrafast 'Quantum Internet'

  3:58:00 PM    Science Lover

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Northwestern University researchers have developed a new switching device that takes quantum communication to a new level. The device is a practical step toward creating a network that takes advantage of the mysterious and powerful world of quantum mechanics.

A new switching device could be used to develop a 'quantum Internet,' where encrypted information would be completely secure, and networking superfast quantum computers. (Credit: iStockphoto/Andrey Prokhorov)

 

The researchers can route quantum bits, or entangled particles of light, at very high speeds along a shared network of fiber-optic cable without losing the entanglement information embedded in the quantum bits. The switch could be used toward achieving two goals of the information technology world: a quantum Internet, where encrypted information would be completely secure, and networking superfast quantum computers.

The device would enable a common transport mechanism, such as the ubiquitous fiber-optic infrastructure, to be shared among many users of quantum information. Such a system could route a quantum bit, such as a photon, to its final destination just like an e-mail is routed across the Internet today.

The research -- a demonstration of the first all-optical switch suitable for single-photon quantum communications -- is published by the journal Physical Review Letters.

"My goal is to make quantum communication devices very practical," said Prem Kumar, AT&T Professor of Information Technology in the McCormick School of Engineering and Applied Science and senior author of the paper. "We work in fiber optics so that as quantum communication matures it can easily be integrated into the existing telecommunication infrastructure."

The bits we all know through standard, or classical, communications only exist in one of two states, either "1" or "0." All classical information is encoded using these ones and zeros. What makes a quantum bit, or qubit, so attractive is it can be both one and zero simultaneously as well as being one or zero. Additionally, two or more qubits at different locations can be entangled -- a mysterious connection that is not possible with ordinary bits.

Researchers need to build an infrastructure that can transport this "superposition and entanglement" (being one and zero simultaneously) for quantum communications and computing to succeed.

The qubit Kumar works with is the photon, a particle of light. A photonic quantum network will require switches that don't disturb the physical characteristics (superposition and entanglement properties) of the photons being transmitted, Kumar says. He and his team built an all-optical, fiber-based switch that does just that while operating at very high speeds.

To demonstrate their switch, the researchers first produced pairs of entangled photons using another device developed by Kumar, called an Entangled Photon Source. "Entangled" means that some physical characteristic (such as polarization as used in 3-D TV) of each pair of photons emitted by this device are inextricably linked. If one photon assumes one state, its mate assumes a corresponding state; this holds even if the two photons are hundreds of kilometers apart.

The researchers used pairs of polarization-entangled photons emitted into standard telecom-grade fiber. One photon of the pair was transmitted through the all-optical switch. Using single-photon detectors, the researchers found that the quantum state of the pair of photons was not disturbed; the encoded entanglement information was intact.

"Quantum communication can achieve things that are not possible with classical communication," said Kumar, director of Northwestern's Center for Photonic Communication and Computing. "This switch opens new doors for many applications, including distributed quantum processing where nodes of small-scale quantum processors are connected via quantum communication links."

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'Elephant Trunks' in Space: WISE Captures Image of Star-Forming Cloud of Dust and Gas

'Elephant Trunks' in Space: WISE Captures Image of Star-Forming Cloud of Dust and Gas

  10:16:00 AM    Science Lover

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NASA's Wide-field Infrared Survey Explorer, or WISE, captured this image of a star-forming cloud of dust and gas, called Sh2-284, located in the constellation of Monoceros. Lining up along the edges of a cosmic hole are several "elephant trunks" -- or monstrous pillars of dense gas and dust.

NASA's Wide-field Infrared Survey Explorer, or WISE, 
captured this image of a star-forming cloud of dust and 
gas located in the constellation of Monoceros. 
(Credit: NASA/JPL-Caltech/UCLA)

 

The most famous examples of elephant trunks are the "Pillars of Creation" found in an iconic image of the Eagle nebula from NASA's Hubble Space Telescope. In this WISE image, the trunks are seen as small columns of gas stretching toward the center of the void in Sh2-284, The most notable one can be seen on the right side at about the 3 o'clock position. It appears as a closed hand with a finger pointing toward the center of the void. That elephant trunk is about 7 light-years long.

Deep inside Sh2-284 resides an open star cluster, called Dolidze 25, which is emitting vast amounts of radiation in all directions, along with stellar winds. These stellar winds and radiation are clearing out a cavern inside the surrounding gas and dust, creating the void seen in the center. The bright green wall surrounding the cavern shows how far out the gas has been eroded. However, some sections of the original gas cloud were much denser than others, and they were able to resist the erosive power of the radiation and stellar winds. These pockets of dense gas remained and protected the gas "downwind" from them, leaving behind the elephant trunks.

Sh2-284 is relatively isolated at the very end of an outer spiral arm of our Milky Way galaxy. In the night sky, it's located in the opposite direction from the center of the Milky Way.

NASA's Jet Propulsion Laboratory, Pasadena, Calif., manages and operates the Wide-field Infrared Survey Explorer for NASA's Science Mission Directorate, Washington. The principal investigator, Edward Wright, is at UCLA. The mission was competitively selected under NASA's Explorers Program managed by the Goddard Space Flight Center, Greenbelt, Md. The science instrument was built by the Space Dynamics Laboratory, Logan, Utah, and the spacecraft was built by Ball Aerospace & Technologies Corp., Boulder, Colo. Science operations and data processing take place at the Infrared Processing and Analysis Center at the California Institute of Technology in Pasadena. Caltech manages JPL for NASA.

More information is online at http://www.nasa.gov/wise and http://wise.astro.ucla.edu and http://jpl.nasa.gov/wise

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New Light-Sensing Mechanism Found in Neurons

New Light-Sensing Mechanism Found in Neurons

  1:06:00 AM    Science Lover

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A UC Irvine research team led by Todd C. Holmes has discovered a second form of phototransduction light sensing in cells that is derived from vitamin B2. This discovery may reveal new information about cellular processes controlled by light.

This image shows blue-light sensing arousal neurons. (Credit: UCI)

For more than 100 years, it had been believed that the phototransduction process was solely based on a chemical derived from vitamin A called retinal. Phototransduction is the conversion of light signals into electrical signals in photoreceptive neurons and underlies both image-forming and non-image-forming light sensing.
In discovering this new light-sensing phototransduction mechanism, the UCI scientists found that phototransduction can also be mediated by a protein called cryptochrome, which uses a B2 vitamin chemical derivative for light sensing. Cryptochromes are blue-light photoreceptors found in circadian and arousal neurons that regulate slow biochemical processes, but this is the first time they have been linked to rapid phototransduction.

Their work appears March 3 on online Express site for the journal Science.

"This is totally novel mechanism that does not depend on retinal," said Holmes, a professor of physiology & biophysics. "This discovery opens whole new technology opportunities for adapting light-sensing proteins to drive medically relevant cellular activities."

This basic science breakthrough -- "which literally and figuratively came 'out of the blue,'" Holmes said -- has implications in the fast-growing field of optogenetics. Optogenetics combines optical and genetic research techniques to probe neural circuits at the high speeds needed to understand brain information processing. In one area, it is being used to understand how treatments such as deep brain massage can aid people with neurodegenerative diseases.

Holmes' team found that cryptochrome mediates phototransduction directly in fruit fly circadian and arousal neurons in response to blue-light wavelengths. The researchers also found that they could genetically express cryptochrome in neurons that are not ordinarily electrically responsive to light to make them light responsive.

Keri Fogel, Kelly Parson and Nicole Dahm of UCI contributed to the study, which received National Institutes of Health support.

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Scientists Create Cell Assembly Line: New Technology Synthesizes Cellular Structures from Simple Starting Materials

Scientists Create Cell Assembly Line: New Technology Synthesizes Cellular Structures from Simple Starting Materials

  12:29:00 AM    Science Lover

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Borrowing a page from modern manufacturing, scientists from the Florida campus of The Scripps Research Institute have built a microscopic assembly line that mass produces synthetic cell-like compartments.

Artist's rendering of cell structure. 
(Credit: iStockphoto/Sebastian Kaulitzki)

 

The new computer-controlled system represents a technological leap forward in the race to create the complex membrane structures of biological cells from simple chemical starting materials.

"Biology is full of synthetic targets that have inspired chemists for more than a century," said Brian Paegel, Scripps Research assistant professor and lead author of a new study published in the Journal of the American Chemical Society. "The lipid membrane assemblies of cells and their organelles pose a daunting challenge to the chemist who wants to synthesize these structures with the same rational approaches used in the preparation of small molecules."

While most cellular components such as genes or proteins are easily prepared in the laboratory, little has been done to develop a method of synthesizing cell membranes in a uniform, automated way. Current approaches are capricious in nature, yielding complex mixtures of products and inefficient cargo loading into the resultant cell-like structures.

The new technology transforms the previously difficult synthesis of cell membranes into a controlled process, customizable over a range of cell sizes, and highly efficient in terms of cargo encapsulation.

The membrane that surrounds all cells, organelles and vesicles -- small subcellular compartments -- consists of a phospholipid bilayer that serves as a barrier, separating an internal space from the external medium.

The new process creates a laboratory version of this bilayer that is formed into small, cell-sized compartments.

How It Works

"The assembly-line process is simple and, from a chemistry standpoint, mechanistically clear," said Sandro Matosevic, research associate and co-author of the study.

A microfluidic circuit generates water droplets in lipid-containing oil. The lipid-coated droplets travel down one branch of a Y-shaped circuit and merge with a second water stream at the Y-junction. The combined flows of droplets in oil and water travel in parallel streams toward a triangular guidepost.

Then, the triangular guide diverts the lipid-coated droplets into the parallel water stream as a wing dam might divert a line of small boats into another part of a river. As the droplets cross the oil-water interface, a second layer of lipids deposits on the droplet, forming a bilayer.

The end result is a continuous stream of uniformly shaped cell-like compartments.

The newly created vesicles range from 20 to 70 micrometers in diameter -- from about the size of a skin cell to that of a human hair. The entire circuit fits on a glass chip roughly the size of a poker chip.

The researchers also tested the synthetic bilayers for their ability to house a prototypical membrane protein. The proteins correctly inserted into the synthetic membrane, proving that they resemble membranes found in biological cells.

"Membranes and compartmentalization are ubiquitous themes in biology," noted Paegel. "We are constructing these synthetic systems to understand why compartmentalized chemistry is a hallmark of life, and how it might be leveraged in therapeutic delivery."

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New Kinds of Superconductivity? Physicists Demonstrate Coveted 'Spin-Orbit Coupling' in Atomic Gases

New Kinds of Superconductivity? Physicists Demonstrate Coveted 'Spin-Orbit Coupling' in Atomic Gases

  1:14:00 PM    Science Lover

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Physicists at the Joint Quantum Institute (JQI), a collaboration of the National Institute of Standards and Technology (NIST) and the University of Maryland-College Park, have for the first time caused a gas of atoms to exhibit an important quantum phenomenon known as spin-orbit coupling. Their technique opens new possibilities for studying and better understanding fundamental physics and has potential applications to quantum computing, next-generation "spintronics" devices and even "atomtronic" devices built from ultracold atoms.

In an ultracold gas of nearly 200,000 rubidium-87 atoms (shown as the large humps) the atoms can occupy one of two energy levels (represented as red and blue); lasers then link together these levels as a function of the atoms' motion. At first atoms in the red and blue energy states occupy the same region (Phase Mixed), then at higher laser strengths, they separate into different regions (Phase Separated). (Credit: Ian Spielman, JQI/NIST)

 

In the researchers' demonstration of spin-orbit coupling, two lasers allow an atom's motion to flip it between a pair of energy states. The new work, published in Nature, demonstrates this effect for the first time in bosons, which make up one of the two major classes of particles. The same technique could be applied to fermions, the other major class of particles, according to the researchers. The special properties of fermions would make them ideal for studying new kinds of interactions between two particles -- for example those leading to novel "p-wave" superconductivity, which may enable a long-sought form of quantum computing known as topological quantum computation.

In an unexpected development, the team also discovered that the lasers modified how the atoms interacted with each other and caused atoms in one energy state to separate in space from atoms in the other energy state.

One of the most important phenomena in quantum physics, spin-orbit coupling describes the interplay that can occur between a particle's internal properties and its external properties. In atoms, it usually describes interactions that only occur within an atom: how an electron's orbit around an atom's core (nucleus) affects the orientation of the electron's internal bar-magnet-like "spin." In semiconductor materials such as gallium arsenide, spin-orbit coupling is an interaction between an electron's spin and its linear motion in a material.

"Spin-orbit coupling is often a bad thing," said JQI's Ian Spielman, senior author of the paper. "Researchers make 'spintronic' devices out of gallium arsenide, and if you've prepared a spin in some desired orientation, the last thing you'd want it to do is to flip to some other spin when it's moving."

"But from the point of view of fundamental physics, spin-orbit coupling is really interesting," he said. "It's what drives these new kinds of materials called 'topological insulators.'"

One of the hottest topics in physics right now, topological insulators are special materials in which location is everything: the ability of electrons to flow depends on where they are located within the material. Most regions of such a material are insulating, and electric current does not flow freely. But in a flat, two-dimensional topological insulator, current can flow freely along the edge in one direction for one type of spin, and the opposite direction for the opposite kind of spin. In 3-D topological insulators, electrons would flow freely on the surface but be inhibited inside the material. While researchers have been making higher and higher quality versions of this special class of material in solids, spin-orbit coupling in trapped ultracold gases of atoms could help realize topological insulators in their purest, most pristine form, as gases are free of impurity atoms and the other complexities of solid materials.

Usually, atoms do not exhibit the same kind of spin-orbit coupling as electrons exhibit in gallium-arsenide crystals. While each individual atom has its own spin-orbit coupling going on between its internal components (electrons and nucleus), the atom's overall motion generally is not affected by its internal energy state.

But the researchers were able to change that. In their experiment, researchers trapped and cooled a gas of about 200,000 rubidium-87 atoms down to 100 nanokelvins, 3 billion times colder than room temperature. The researchers selected a pair of energy states, analogous to the "spin-up" and "spin-down" states in an electron, from the available atomic energy levels. An atom could occupy either of these "pseudospin" states. Then researchers shined a pair of lasers on the atoms so as to change the relationship between the atom's energy and its momentum (its mass times velocity), and therefore its motion. This created spin-orbit coupling in the atom: the moving atom flipped between its two "spin" states at a rate that depended upon its velocity.

"This demonstrates that the idea of using laser light to create spin-orbit coupling in atoms works. This is all we expected to see," Spielman said. "But something else really neat happened."

They turned up the intensity of their lasers, and atoms of one spin state began to repel the atoms in the other spin state, causing them to separate.

"We changed fundamentally how these atoms interacted with one another," Spielman said. "We hadn't anticipated that and got lucky."

The rubidium atoms in the researchers' experiment were bosons, sociable particles that can all crowd into the same space even if they possess identical values in their properties including spin. But Spielman's calculations show that they could also create this same effect in ultracold gases of fermions. Fermions, the more antisocial type of atoms, cannot occupy the same space when they are in an identical state. And compared to other methods for creating new interactions between fermions, the spin states would be easier to control and longer lived.

A spin-orbit-coupled Fermi gas could interact with itself because the lasers effectively split each atom into two distinct components, each with its own spin state, and two such atoms with different velocities could then interact and pair up with one other. This kind of pairing opens up possibilities, Spielman said, for studying novel forms of superconductivity, particularly "p-wave" superconductivity, in which two paired atoms have a quantum-mechanical phase that depends on their relative orientation. Such p-wave superconductors may enable a form of quantum computing known as topological quantum computation.

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Liver, Not Brain, May Be Origin of Alzheimer’s Plaques

Liver, Not Brain, May Be Origin of Alzheimer’s Plaques

  10:02:00 AM    Science Lover

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Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists' ideas about Alzheimer's disease -- pointing to the liver instead of the brain as the source of the "amyloid" that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple approach for Alzheimer's prevention and treatment.

New research suggests that the liver instead of the brain 
may be the source of the "amyloid" that deposits as brain 
plaques associated with Alzheimer's disease. 
(Credit: iStockphoto/David Marchal)

 

The study was published online March 3 in The Journal of Neuroscience Research.

In the study, the scientists used a mouse model for Alzheimer's disease to identify genes that influence the amount of amyloid that accumulates in the brain. They found three genes that protected mice from brain amyloid accumulation and deposition. For each gene, lower expression in the liver protected the mouse brain. One of the genes encodes presenilin -- a cell membrane protein believed to contribute to the development of human Alzheimer's.

"This unexpected finding holds promise for the development of new therapies to fight Alzheimer's," said Scripps Research Professor Greg Sutcliffe, who led the study. "This could greatly simplify the challenge of developing therapies and prevention."

An estimated 5.1 million Americans have Alzheimer's disease, including nearly half of people age 85 and older. By 2050, the number of people age 65 and over with this disease will range from 11 million to 16 million unless science finds a way to prevent or effectively treat it. In addition to the human misery caused by the disease, there is the unfathomable cost. A new report from the Alzheimer's Association shows that in the absence of disease-modifying treatments, the cumulative costs of care for people with Alzheimer's from 2010 to 2050 will exceed $20 trillion.

A Genetic Search-and-Find Mission

In trying to help solve the Alzheimer's puzzle, in the past few years Sutcliffe and his collaborators have focused their research on naturally occurring, inherited differences in neurological disease susceptibility among different mouse strains, creating extensive databases cataloging gene activity in different tissues, as measured by mRNA accumulation. These data offer up maps of trait expression that can be superimposed on maps of disease modifier genes.

As is the case with nearly all scientific discovery, Sutcliffe's research builds on previous findings. Several years ago, researchers at Case Western Reserve mapped three genes that modify the accumulation of pathological beta amyloid in the brains of a transgenic mouse model of Alzheimer's disease to large chromosomal regions, each containing hundreds of genes. The Case Western scientists used crosses between the B6 and D2 strains of mice, studying more than 500 progeny.

Using the results from this study, Sutcliffe turned his databases of gene expression to the mouse model of Alzheimer's, looking for differences in gene expression that correlated with differences in disease susceptibility between the B6 and D2 strains. This intensive work involved writing computer programs that identified each genetic difference that distinguished the B6 and D2 genomes, then running mathematical correlation analysis (known as regression analysis) of each difference. Correlations were made between the genotype differences (B6 or D2) and the amount of mRNA product made from each of the more than 25,000 genes in a particular tissue in the 40 recombinant inbred mouse strains. These correlations were repeated 10 times to cover 10 tissues, the liver being one of them.

"A key aspect of this work was learning how to ask questions of massive data sets to glean information about the identities of heritable modifier genes," Sutcliffe said. "This was novel and, in a sense, groundbreaking work: we were inventing a new way to identify modifier genes, putting all of these steps together and automating the process. We realized we could learn about how a transgene's pathogenic effect was being modified without studying the transgenic mice ourselves."

Looking for a Few Good Candidates

Sutcliffe's gene hunt offered up good matches, candidates, for each of the three disease modifier genes discovered by the Case Western scientists, and one of these candidates -- the mouse gene corresponding to a gene known to predispose humans carrying particular variations of it to develop early-onset Alzheimer's disease -- was of special interest to his team.

"The product of that gene, called Presenilin2, is part of an enzyme complex involved in the generation of pathogenic beta amyloid," Sutcliffe explained. "Unexpectedly, heritable expression of Presenilin2 was found in the liver but not in the brain. Higher expression of Presenilin2 in the liver correlated with greater accumulation of beta amyloid in the brain and development of Alzheimer's-like pathology."

This finding suggested that significant concentrations of beta amyloid might originate in the liver, circulate in the blood, and enter the brain. If true, blocking production of beta amyloid in the liver should protect the brain.

To test this hypothesis, Sutcliffe's team set up an in vivo experiment using wild-type mice since they would most closely replicate the natural beta amyloid-producing environment. "We reasoned that if brain amyloid was being born in the liver and transported to the brain by the blood, then that should be the case in all mice," Sutcliffe said, "and one would predict in humans, too."

The mice were administered imatinib (trade name Gleevec, an FDA-approved cancer drug), a relatively new drug currently approved for treatment of chronic myelogenous leukemia and gastrointestinal tumors. The drug potently reduces the production of beta amyloid in neuroblastoma cells transfected by amyloid precursor protein (APP) and also in cell-free extracts prepared from the transfected cells. Importantly, Gleevec has poor penetration of the blood-brain barrier in both mice and humans.

"This characteristic of the drug is precisely why we chose to use it," Sutcliffe explained. "Because it doesn't penetrate the blood-brain barrier, we were able to focus on the production of amyloid outside of the brain and how that production might contribute to amyloid that accumulates in the brain, where it is associated with disease."

The mice were injected with Gleevec twice a day for seven days; then plasma and brain tissue were collected, and the amount of beta amyloid in the blood and brain was measured. The findings: the drug dramatically reduced beta amyloid not only in the blood, but also in the brain where the drug cannot penetrate. Thus, an appreciable portion of brain amyloid must originate outside of the brain, and imatinib represents a candidate for preventing and treating Alzheimer's.

As for the future of this research, Sutcliffe says he hopes to find a partner and investors to move the work into clinical trials and new drug development.

In addition to Sutcliffe, the authors of the study, titled "Peripheral reduction of β-amyloid is sufficient to reduce brain Aβ: implications for Alzheimer's disease," include Peter Hedlund and Elizabeth Thomas of Scripps Research, and Floyd Bloom and Brian Hilbush of ModGene, LLC, which funded the project.

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Parts of Brain Can Switch Functions: In People Born Blind, Brain Regions That Usually Process Vision Can Tackle Language

Parts of Brain Can Switch Functions: In People Born Blind, Brain Regions That Usually Process Vision Can Tackle Language

  9:52:00 AM    Science Lover

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When your brain encounters sensory stimuli, such as the scent of your morning coffee or the sound of a honking car, that input gets shuttled to the appropriate brain region for analysis. The coffee aroma goes to the olfactory cortex, while sounds are processed in the auditory cortex.

MRI scan of brain. (Credit: iStockphoto)

 

That division of labor suggests that the brain's structure follows a predetermined, genetic blueprint. However, evidence is mounting that brain regions can take over functions they were not genetically destined to perform. In a landmark 1996 study of people blinded early in life, neuroscientists showed that the visual cortex could participate in a nonvisual function -- reading Braille.

Now, a study from MIT neuroscientists shows that in individuals born blind, parts of the visual cortex are recruited for language processing. The finding suggests that the visual cortex can dramatically change its function -- from visual processing to language -- and it also appears to overturn the idea that language processing can only occur in highly specialized brain regions that are genetically programmed for language tasks.

"Your brain is not a prepackaged kind of thing. It doesn't develop along a fixed trajectory, rather, it's a self-building toolkit. The building process is profoundly influenced by the experiences you have during your development," says Marina Bedny, an MIT postdoctoral associate in the Department of Brain and Cognitive Sciences and lead author of the study, which appears in the Proceedings of the National Academy of Sciences the week of Feb. 28.

Flexible connections

For more than a century, neuroscientists have known that two specialized brain regions -- called Broca's area and Wernicke's area -- are necessary to produce and understand language, respectively. Those areas are thought to have intrinsic properties, such as specific internal arrangement of cells and connectivity with other brain regions, which make them uniquely suited to process language.

Other functions -- including vision and hearing -- also have distinct processing centers in the sensory cortices. However, there appears to be some flexibility in assigning brain functions. Previous studies in animals (in the laboratory of Mriganka Sur, MIT professor of brain and cognitive sciences) have shown that sensory brain regions can process information from a different sense if input is rewired to them surgically early in life. For example, connecting the eyes to the auditory cortex can provoke that brain region to process images instead of sounds.

Until now, no such evidence existed for flexibility in language processing. Previous studies of congenitally blind people had shown some activity in the left visual cortex of blind subjects during some verbal tasks, such as reading Braille, but no one had shown that this might indicate full-fledged language processing.

Bedny and her colleagues, including senior author Rebecca Saxe, assistant professor of brain and cognitive sciences, and Alvaro Pascual-Leone, professor of neurology at Harvard Medical School, set out to investigate whether visual brain regions in blind people might be involved in more complex language tasks, such as processing sentence structure and analyzing word meanings.

To do that, the researchers scanned blind subjects (using functional magnetic resonance imaging) as they performed a sentence comprehension task. The researchers hypothesized that if the visual cortex was involved in language processing, those brain areas should show the same sensitivity to linguistic information as classic language areas such as Broca's and Wernicke's areas.

They found that was indeed the case -- visual brain regions were sensitive to sentence structure and word meanings in the same way as classic language regions, Bedny says. "The idea that these brain regions could go from vision to language is just crazy," she says. "It suggests that the intrinsic function of a brain area is constrained only loosely, and that experience can have really a big impact on the function of a piece of brain tissue."

Bedny notes that the research does not refute the idea that the human brain needs Broca's and Wernicke's areas for language. "We haven't shown that every possible part of language can be supported by this part of the brain [the visual cortex]. It just suggests that a part of the brain can participate in language processing without having evolved to do so," she says.

Redistribution

One unanswered question is why the visual cortex would be recruited for language processing, when the language processing areas of blind people already function normally. According to Bedny, it may be the result of a natural redistribution of tasks during brain development.

"As these brain functions are getting parceled out, the visual cortex isn't getting its typical function, which is to do vision. And so it enters this competitive game of who's going to do what. The whole developmental dynamic has changed," she says.

This study, combined with other studies of blind people, suggest that different parts of the visual cortex get divvied up for different functions during development, Bedny says. A subset of (left-brain) visual areas appears to be involved in language, including the left primary visual cortex.

It's possible that this redistribution gives blind people an advantage in language processing. The researchers are planning follow-up work in which they will study whether blind people perform better than sighted people in complex language tasks such as parsing complicated sentences or performing language tests while being distracted.

The researchers are also working to pinpoint more precisely the visual cortex's role in language processing, and they are studying blind children to figure out when during development the visual cortex starts processing language.
 

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Atomic Antennas Transmit Quantum Information Across a Microchip

Atomic Antennas Transmit Quantum Information Across a Microchip

  12:48:00 AM    Science Lover

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The Austrian research group led by physicist Rainer Blatt suggests a fundamentally novel architecture for quantum computation. They have experimentally demonstrated quantum antennas, which enable the exchange of quantum information between two separate memory cells located on a computer chip. This offers new opportunities to build practical quantum computers.

Quantum antennae enable the exchange of quantum 
information between two separate memory cells located 
on a computer chip. (Credit: Harald Ritsch)

 

The researchers have published their work in the scientific journal Nature.

Six years ago scientists at the University of Innsbruck realized the first quantum byte -- a quantum computer with eight entangled quantum particles; a record that still stands. "Nevertheless, to make practical use of a quantum computer that performs calculations, we need a lot more quantum bits," says Prof. Rainer Blatt, who, with his research team at the Institute for Experimental Physics, created the first quantum byte in an electromagnetic ion trap. "In these traps we cannot string together large numbers of ions and control them simultaneously."

To solve this problem, the scientists have started to design a quantum computer based on a system of many small registers, which have to be linked. To achieve this, Innsbruck quantum physicists have now developed a revolutionary approach based on a concept formulated by theoretical physicists Ignacio Cirac and Peter Zoller. In their experiment, the physicists electromagnetically coupled two groups of ions over a distance of about 50 micrometers. Here, the motion of the particles serves as an antenna. "The particles oscillate like electrons in the poles of a TV antenna and thereby generate an electromagnetic field," explains Blatt. "If one antenna is tuned to the other one, the receiving end picks up the signal of the sender, which results in coupling." The energy exchange taking place in this process could be the basis for fundamental computing operations of a quantum computer.

Antennas amplify transmission

"We implemented this new concept in a very simple way," explains Rainer Blatt. In a miniaturized ion trap a double-well potential was created, trapping the calcium ions. The two wells were separated by 54 micrometers. "By applying a voltage to the electrodes of the ion trap, we were able to match the oscillation frequencies of the ions," says Blatt.

"This resulted in a coupling process and an energy exchange, which can be used to transmit quantum information." A direct coupling of two mechanical oscillations at the quantum level has never been demonstrated before. In addition, the scientists show that the coupling is amplified by using more ions in each well. "These additional ions function as antennas and increase the distance and speed of the transmission," says Rainer Blatt, who is excited about the new concept. This work constitutes a promising approach for building a fully functioning quantum computer.

"The new technology offers the possibility to distribute entanglement. At the same time, we are able to target each memory cell individually," explains Rainer Blatt. The new quantum computer could be based on a chip with many micro traps, where ions communicate with each other through electromagnetic coupling. This new approach represents an important step towards practical quantum technologies for information processing.

The quantum researchers are supported by the Austrian Science Fund FWF, the European Union, the European Research Council and the Federation of Austrian Industries Tyrol.

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