High-speed encryption to secure future internet

High-speed encryption to secure future internet

  5:01:00 PM    Science Lover

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In a bid to fight against the future cyber threats, scientists have developed a new system with high-speed encryption properties that drives quantum computers to create theoretically hack-proof forms of data encryption. The novel system is capable of creating and distributing encryption codes at megabit-per-second rates, which is five to 10 times faster than existing methods and on par with current internet speeds when running several systems in parallel. The technique is secure from common attacks, even in the face of equipment flaws that could open up leaks.

"We are now likely to have a functioning quantum computer that might be able to start breaking the existing cryptographic codes in the near future," said Daniel Gauthier, Professor at The Ohio State University. "We really need to be thinking hard now of different techniques that we could use for trying to secure the internet," Gauthier added, in the paper appearing in the journal Science Advances. For the new system to work, both the hacker as well as the sender must have access to the same key, and it must be kept secret. The novel system uses a weakened laser to encode information or transmit keys on individual photons of light, but also packs more information onto each photon, making the technique faster. By adjusting the time at which the photon is released, and a property of the photon called the phase, the new system can encode two bits of information per photon instead of one.

This trick, paired with high-speed detectors powers the system to transmit keys five to 10 times faster than other methods. "It was changing these additional properties of the photon that allowed us to almost double the secure key rate that we were able to obtain if we hadn't done that," Gauthier said.

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Manipulating memory with light: Scientists erase specific memories in mice

Manipulating memory with light: Scientists erase specific memories in mice

  8:13:00 PM    Science Lover

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Just look into the light: not quite, but researchers at the UC Davis Center for Neuroscience and Department of Psychology have used light to erase specific memories in mice, and proved a basic theory of how different parts of the brain work together to retrieve episodic memories.

During memory retrieval, cells in the hippocampus
connect to cells in the brain cortex.

Credit: Photo illustration by Kazumasa Tanaka and 
Brian Wiltgen/UC Davis

Optogenetics, pioneered by Karl Diesseroth at Stanford University, is a new technique for manipulating and studying nerve cells using light. The techniques of optogenetics are rapidly becoming the standard method for investigating brain function.

Kazumasa Tanaka, Brian Wiltgen and colleagues at UC Davis applied the technique to test a long-standing idea about memory retrieval. For about 40 years, Wiltgen said, neuroscientists have theorized that retrieving episodic memories -- memories about specific places and events -- involves coordinated activity between the cerebral cortex and the hippocampus, a small structure deep in the brain.

"The theory is that learning involves processing in the cortex, and the hippocampus reproduces this pattern of activity during retrieval, allowing you to re-experience the event," Wiltgen said. If the hippocampus is damaged, patients can lose decades of memories.

But this model has been difficult to test directly, until the arrival of optogenetics.

Wiltgen and Tanaka used mice genetically modified so that when nerve cells are activated, they both fluoresce green and express a protein that allows the cells to be switched off by light. They were therefore able both to follow exactly which nerve cells in the cortex and hippocampus were activated in learning and memory retrieval, and switch them off with light directed through a fiber-optic cable.

They trained the mice by placing them in a cage where they got a mild electric shock. Normally, mice placed in a new environment will nose around and explore. But when placed in a cage where they have previously received a shock, they freeze in place in a "fear response."

Tanaka and Wiltgen first showed that they could label the cells involved in learning and demonstrate that they were reactivated during memory recall. Then they were able to switch off the specific nerve cells in the hippocampus, and show that the mice lost their memories of the unpleasant event. They were also able to show that turning off other cells in the hippocampus did not affect retrieval of that memory, and to follow fibers from the hippocampus to specific cells in the cortex.

"The cortex can't do it alone, it needs input from the hippocampus," Wiltgen said. "This has been a fundamental assumption in our field for a long time and Kazu’s data provides the first direct evidence that it is true."

They could also see how the specific cells in the cortex were connected to the amygdala, a structure in the brain that is involved in emotion and in generating the freezing response.

Co-authors are Aleksandr Pevzner, Anahita B. Hamidi, Yuki Nakazawa and Jalina Graham, all at the Center for Neuroscience. The work was funded by grants from the Whitehall Foundation, McKnight Foundation, Nakajima Foundation and the National Science Foundation.

Story Source:
The above story is based on materials provided by University of California - Davis. Note: Materials may be edited for content and length.

Journal Reference:
Kazumasa Z. Tanaka, Aleksandr Pevzner, Anahita B. Hamidi, Yuki Nakazawa, Jalina Graham, Brian J. Wiltgen. Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval. Neuron, 2014 DOI: 10.1016/j.neuron.2014.09.037

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Incredibly light, strong materials recover original shape after being smashed

Incredibly light, strong materials recover original shape after being smashed

  4:10:00 PM    Science Lover

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Materials scientists have developed a method for creating new structural materials by taking advantage of the unusual properties that solids can have at the nanometer scale. They have used the method to produce a ceramic (e.g., a piece of chalk or a brick) that contains about 99.9 percent air yet is incredibly strong and can recover its original shape after being smashed by more than 50 percent.

This sequence shows how the Greer Lab's three-dimensional,
ceramic nanolattices can recover after being compressed by
more than 50 percent. Clockwise, from left to right, an alumina
nanolattice before compression, during compression, fully
compressed, and recovered following compression.

Credit: Lucas Meza/Caltech

Imagine a balloon that could float without using any lighter-than-air gas. Instead, it could simply have all of its air sucked out while maintaining its filled shape. Such a vacuum balloon, which could help ease the world's current shortage of helium, can only be made if a new material existed that was strong enough to sustain the pressure generated by forcing out all that air while still being lightweight and flexible. 

Caltech materials scientist Julia Greer and her colleagues are on the path to developing such a material and many others that possess unheard-of combinations of properties. For example, they might create a material that is thermally insulating but also extremely lightweight, or one that is simultaneously strong, lightweight, and nonbreakable -- properties that are generally thought to be mutually exclusive.

Greer's team has developed a method for constructing new structural materials by taking advantage of the unusual properties that solids can have at the nanometer scale, where features are measured in billionths of meters. In a paper published in the September 12 issue of the journal Science, the Caltech researchers explain how they used the method to produce a ceramic (e.g., a piece of chalk or a brick) that contains about 99.9 percent air yet is incredibly strong, and that can recover its original shape after being smashed by more than 50 percent.

"Ceramics have always been thought to be heavy and brittle," says Greer, a professor of materials science and mechanics in the Division of Engineering and Applied Science at Caltech. "We're showing that in fact, they don't have to be either. This very clearly demonstrates that if you use the concept of the nanoscale to create structures and then use those nanostructures like LEGO to construct larger materials, you can obtain nearly any set of properties you want. You can create materials by design."

The researchers use a direct laser writing method called two-photon lithography to "write" a three-dimensional pattern in a polymer by allowing a laser beam to crosslink and harden the polymer wherever it is focused. The parts of the polymer that were exposed to the laser remain intact while the rest is dissolved away, revealing a three-dimensional scaffold. That structure can then be coated with a thin layer of just about any kind of material -- a metal, an alloy, a glass, a semiconductor, etc. Then the researchers use another method to etch out the polymer from within the structure, leaving a hollow architecture.

The applications of this technique are practically limitless, Greer says. Since pretty much any material can be deposited on the scaffolds, the method could be particularly useful for applications in optics, energy efficiency, and biomedicine. For example, it could be used to reproduce complex structures such as bone, producing a scaffold out of biocompatible materials on which cells could proliferate.

In the latest work, Greer and her students used the technique to produce what they call three-dimensional nanolattices that are formed by a repeating nanoscale pattern. After the patterning step, they coated the polymer scaffold with a ceramic called alumina (i.e., aluminum oxide), producing hollow-tube alumina structures with walls ranging in thickness from 5 to 60 nanometers and tubes from 450 to 1,380 nanometers in diameter.

Greer's team next wanted to test the mechanical properties of the various nanolattices they created. Using two different devices for poking and prodding materials on the nanoscale, they squished, stretched, and otherwise tried to deform the samples to see how they held up.

They found that the alumina structures with a wall thickness of 50 nanometers and a tube diameter of about 1 micron shattered when compressed. That was not surprising given that ceramics, especially those that are porous, are brittle. However, compressing lattices with a lower ratio of wall thickness to tube diameter -- where the wall thickness was only 10 nanometers -- produced a very different result.

"You deform it, and all of a sudden, it springs back," Greer says. "In some cases, we were able to deform these samples by as much as 85 percent, and they could still recover."

To understand why, consider that most brittle materials such as ceramics, silicon, and glass shatter because they are filled with flaws -- imperfections such as small voids and inclusions. The more perfect the material, the less likely you are to find a weak spot where it will fail. Therefore, the researchers hypothesize, when you reduce these structures down to the point where individual walls are only 10 nanometers thick, both the number of flaws and the size of any flaws are kept to a minimum, making the whole structure much less likely to fail.

"One of the benefits of using nanolattices is that you significantly improve the quality of the material because you're using such small dimensions," Greer says. "It's basically as close to an ideal material as you can get, and you get the added benefit of needing only a very small amount of material in making them."

The Greer lab is now aggressively pursuing various ways of scaling up the production of these so-called meta-materials.

Story Source: http://www.sciencedaily.com/releases/2014/09/140911135450.htm

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Report:A Semi-Floating Gate Transistor for Low-Voltage Ultrafast Memory and Sensing Operation

Report:A Semi-Floating Gate Transistor for Low-Voltage Ultrafast Memory and Sensing Operation

  10:19:00 AM    Science Lover

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Researchers at Fudan University in China have discovered a way to speed up traditional computer transistors by embedding tunneling field-effect transistors (TFETs) in them. In their paper published in the journal Science, the team describes how embedding TFETs in such transistors allows for them to be run with less power, which in turn causes them to run faster.

Schematic view of an SFG memory cell. A pn junction diode between the FG and D makes the FG semi-floating. The device’s symbolic representation is also shown. Credit: Science 9 August 2013: Vol. 341 no. 6146 pp. 640-643 DOI: 10.1126/science.1240961

Most modern computers are run with either metal-oxide-semiconductor field-effect transistors (MOSFETs) or a variation of them called floating-gate (FG) MOSFETs. Such transistors are now reaching their physical limit as far as how thin they can be—just a few atoms thick. For that reason, researchers have been looking for other ways to get more bang for their buck. In this new effort, the researchers turned to TFETs, which use quantum tunneling to move electrons through very thin material.

TFETs have traditionally been used in very low power devices. In this endeavor, they researchers created a TFET that could be used to control the electrodes that monitor the flow of electricity into a MOSFET—in this case, the floating-gate variety (it has an additional electrode gate that allows a charge to be retained). The idea is that if the gate could be made to open and close faster, the transistor as a whole would operate faster. Current chips require a build-up of charge before the gate can be opened or closed—which requires time. TFETs, because they require less power, don't take as long to do their work, thus embedding one in a floating gate-MOSFET would alleviate the necessity of power buildup prior to gate changes, allowing for quicker opening and closing. That's exactly what the team in China has done. Testing thus far has shown MOSFETs with embedded TFETs have improved transistor speeds as well as reduced power requirements.

The team reports that because of the way their TFETs are constructed, embedding them in current model MOSFETs should not require reconfiguration or the use of any new materials. This means that the new TFET technology could be put into use almost immediately, bumping up the speed of computers and hand held devices while lessening the amount of energy used, resulting in longer battery life.

More information: A Semi-Floating Gate Transistor for Low-Voltage Ultrafast Memory and Sensing Operation, Science 9 August 2013: Vol. 341 no. 6146 pp. 640-643 DOI: 10.1126/science.1240961

ABSTRACT

As the semiconductor devices of integrated circuits approach the physical limitations of scaling, alternative transistor and memory designs are needed to achieve improvements in speed, density, and power consumption. We report on a transistor that uses an embedded tunneling field-effect transistor for charging and discharging the semi-floating gate. This transistor operates at low voltages (?2.0 volts), with a large threshold voltage window of 3.1 volts, and can achieve ultra–high-speed writing operations (on time scales of ~1 nanosecond). A linear dependence of drain current on light intensity was observed when the transistor was exposed to light, so possible applications include image sensing with high density and performance.

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Imagination Can Change What We Hear and See

Imagination Can Change What We Hear and See

  1:24:00 PM    Science Lover

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A study from Karolinska Institut in Sweden shows, that our imagination may affect how we experience the world more than we perhaps think. What we imagine hearing or seeing "in our head" can change our actual perception. The study, which is published in the scientific journal Current Biology, sheds new light on a classic question in psychology and neuroscience -- about how our brains combine information from the different senses.

Illusion of colliding objects. (Credit: Image courtesy of Karolinska Institutet)

"We often think about the things we imagine and the things we perceive as being clearly dissociable," says Christopher Berger, doctoral student at the Department of Neuroscience and lead author of the study. "However, what this study shows is that our imagination of a sound or a shape changes how we perceive the world around us in the same way actually hearing that sound or seeing that shape does. Specifically, we found that what we imagine hearing can change what we actually see, and what we imagine seeing can change what we actually hear."

The study consists of a series of experiments that make use of illusions in which sensory information from one sense changes or distorts one's perception of another sense. Ninety-six healthy volunteers participated in total.

In the first experiment, participants experienced the illusion that two passing objects collided rather than passed by one-another when they imagined a sound at the moment the two objects met. In a second experiment, the participants' spatial perception of a sound was biased towards a location where they imagined seeing the brief appearance of a white circle. In the third experiment, the participants' perception of what a person was saying was changed by their imagination of a particular sound.

According to the scientists, the results of the current study may be useful in understanding the mechanisms by which the brain fails to distinguish between thought and reality in certain psychiatric disorders such as schizophrenia. Another area of use could be research on brain computer interfaces, where paralyzed individuals' imagination is used to control virtual and artificial devices.

"This is the first set of experiments to definitively establish that the sensory signals generated by one's imagination are strong enough to change one's real-world perception of a different sensory modality" says Professor Henrik Ehrsson, the principle investigator behind the study.

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A Telescope for Your Eye: New Contact Lens Design May Improve Sight of Patients With Macular Degeneration

A Telescope for Your Eye: New Contact Lens Design May Improve Sight of Patients With Macular Degeneration

  9:04:00 PM    Science Lover

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Contact lenses correct many people's eyesight but do nothing to improve the blurry vision of those suffering from age-related macular degeneration (AMD), the leading cause of blindness among older adults in the western world. That's because simply correcting the eye's focus cannot restore the central vision lost from a retina damaged by AMD. Now a team of researchers from the United States and Switzerland led by University of California San Diego Professor Joseph Ford has created a slim, telescopic contact lens that can switch between normal and magnified vision. With refinements, the system could offer AMD patients a relatively unobtrusive way to enhance their vision.

This image shows five views of the switchable telescopic contact lens. a) From front. b) From back. c) On the mechanical model eye. d) With liquid crystal glasses. Here, the glasses block the unmagnified central portion of the lens. e) With liquid crystal glasses. Here, the central portion is not blocked. (Credit: Optics Express)

The team reports its work in the Optical Society's (OSA) open-access journal Optics Express.

Visual aids that magnify incoming light help AMD patients see by spreading light around to undamaged parts of the retina. These optical magnifiers can assist patients with a variety of important everyday tasks such as reading, identification of faces, and self-care. But these aids have not gained widespread acceptance because they either use bulky spectacle-mounted telescopes that interfere with social interactions, or micro-telescopes that require surgery to implant into the patient's eye.

"For a visual aid to be accepted it needs to be highly convenient and unobtrusive," says co-author Eric Tremblay of the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland. A contact lens is an "attractive compromise" between the head-mounted telescopes and surgically implanted micro-telescopes, Tremblay says.

The new lens system developed by Ford's team uses tightly fitting mirror surfaces to make a telescope that has been integrated into a contact lens just over a millimeter thick. The lens has a dual modality: the center of the lens provides unmagnified vision, while the ring-shaped telescope located at the periphery of the regular contact lens magnifies the view 2.8 times.

To switch back and forth between the magnified view and normal vision, users would wear a pair of liquid crystal glasses originally made for viewing 3-D televisions. These glasses selectively block either the magnifying portion of the contact lens or its unmagnified center. The liquid crystals in the glasses electrically change the orientation of polarized light, allowing light with one orientation or the other to pass through the glasses to the contact lens.

The team tested their design both with computer modeling and by fabricating the lens. They also created a life-sized model eye that they used to capture images through their contact lens-eyeglasses system. In constructing the lens, researchers relied on a robust material commonly used in early contact lenses called polymethyl methacrylate (PMMA). The team needed that robustness because they had to place tiny grooves in the lens to correct for aberrant color caused by the lens' shape, which is designed to conform to the human eye.

Tests showed that the magnified image quality through the contact lens was clear and provided a much larger field of view than other magnification approaches, but refinements are necessary before this proof-of-concept system could be used by consumers. The researchers report that the grooves used to correct color had the side effect of degrading image quality and contrast. These grooves also made the lens unwearable unless it is surrounded by a smooth, soft "skirt," something commonly used with rigid contact lenses today. Finally, the robust material they used, PMMA, is not ideal for contact lenses because it is gas-impermeable and limits wear to short periods of time.

The team is currently pursuing a similar design that will still be switchable from normal to telescopic vision, but that will use gas-permeable materials and will correct aberrant color without the need for grooves to bend the light. They say they hope their design will offer improved performance and better sight for people with macular degeneration, at least until a more permanent remedy for AMD is available.

"In the future, it will hopefully be possible to go after the core of the problem with effective treatments or retinal prosthetics," Tremblay says. "The ideal is really for magnifiers to become unnecessary. Until we get there, however, contact lenses may provide a way to make AMD a little less debilitating."

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Breaking habits before they start

Breaking habits before they start

  7:57:00 AM    Science Lover

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Our daily routines can become so ingrained that we perform them automatically, such as taking the same route to work every day. Some behaviors, such as smoking or biting your fingernails, become so habitual that we can't stop even if we want to.

Although breaking habits can be hard, MIT neuroscientists have now shown that they can prevent them from taking root in the first place, in rats learning to run a maze to earn a reward. The researchers first demonstrated that activity in two distinct brain regions is necessary in order for habits to crystallize. Then, they were able to block habits from forming by interfering with activity in one of the brain regions—the infralimbic (IL) cortex, which is located in the prefrontal cortex.

The MIT researchers, led by Institute Professor Ann Graybiel, used a technique called optogenetics to block activity in the IL cortex. This allowed them to control cells of the IL cortex using light. When the cells were turned off during every maze training run, the rats still learned to run the maze correctly, but when the reward was made to taste bad, they stopped, showing that a habit had not formed. If it had, they would keep going back by habit.

"It's usually so difficult to break a habit," Graybiel says. "It's also difficult to have a habit not form when you get a reward for what you're doing. But with this manipulation, it's absolutely easy. You just turn the light on, and bingo."

Graybiel, a member of MIT's McGovern Institute for Brain Research, is the senior author of a paper describing the findings in the June 27 issue of the journal Neuron. Kyle Smith, a former MIT postdoc who is now an assistant professor at Dartmouth College, is the paper's lead author.

Patterns of habitual behavior

Previous studies of how habits are formed and controlled have implicated the IL cortex as well as the striatum, a part of the brain related to addiction and repetitive behavioral problems, as well as normal functions such as decision-making, planning and response to reward. It is believed that the motor patterns needed to execute a habitual behavior are stored in the striatum and its circuits.

Recent studies from Graybiel's lab have shown that disrupting activity in the IL cortex can block the expression of habits that have already been learned and stored in the striatum. Last year, Smith and Graybiel found that the IL cortex appears to decide which of two previously learned habits will be expressed.

"We have evidence that these two areas are important for habits, but they're not connected at all, and no one has much of an idea of what the cells are doing as a habit is formed, as the habit is lost, and as a new habit takes over," Smith says.

To investigate that, Smith recorded activity in cells of the IL cortex as rats learned to run a maze. He found activity patterns very similar to those that appear in the striatum during habit formation. Several years ago, Graybiel found that a distinctive "task-bracketing" pattern develops when habits are formed. This means that the cells are very active when the animal begins its run through the maze, are quiet during the run, and then fire up again when the task is finished.

This kind of pattern "chunks" habits into a large unit that the brain can simply turn on when the habitual behavior is triggered, without having to think about each individual action that goes into the habitual behavior.

The researchers found that this pattern took longer to appear in the IL cortex than in the striatum, and it was also less permanent. Unlike the pattern in the striatum, which remains stored even when a habit is broken, the IL cortex pattern appears and disappears as habits are formed and broken. This was the clue that the IL cortex, not the striatum, was tracking the development of the habit.

Multiple layers of control

The researchers' ability to optogenetically block the formation of new habits suggests that the IL cortex not only exerts real-time control over habits and compulsions, but is also needed for habits to form in the first place.

"The previous idea was that the habits were stored in the sensorimotor system and this cortical area was just selecting the habit to be expressed. Now we think it's a more fundamental contribution to habits, that the IL cortex is more actively making this happen," Smith says.

This arrangement offers multiple layers of control over habitual behavior, which could be advantageous in reining in automatic behavior, Graybiel says. It is also possible that the IL cortex is contributing specific pieces of the habitual behavior, in addition to exerting control over whether it occurs, according to the researchers. They are now trying to determine whether the IL cortex and the striatum are communicating with and influencing each other, or simply acting in parallel.

The study suggests a new way to look for abnormal activity that might cause disorders of repetitive behavior, Smith says. Now that the researchers have identified the neural signature of a normal habit, they can look for signs of habitual behavior that is learned too quickly or becomes too rigid. Finding such a signature could allow scientists to develop new ways to treat disorders of repetitive behavior by using deep brain stimulation, which uses electronic impulses delivered by a pacemaker to suppress abnormal brain activity.

Journal reference: Neuron

Provided by Massachusetts Institute of Technolog

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Consider a Text for Teen Suicide Prevention and Intervention, Research Suggests

Consider a Text for Teen Suicide Prevention and Intervention, Research Suggests

  11:38:00 PM    Science Lover

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Adolescents Commonly Use Social Media to Reach Out When They are Depressed

"Obviously this is a place where adolescents are expressing their feelings. It leads me to believe that we need to think about using social media as an intervention and as a way to connect with people."

Teens and young adults are making use of social networking sites and mobile technology to express suicidal thoughts and intentions as well as to reach out for help, two studies suggest.

An analysis of about one month of public posts on MySpace revealed 64 comments in which adolescents expressed a wish to die. Researchers conducted a follow-up survey of young adults and found that text messages were the second-most common way for respondents to seek help when they felt depressed. Talking to a friend or family member ranked first.

These young adults also said they would be least likely to use suicide hotlines or online suicide support groups – the most prevalent strategy among existing suicide-prevention initiatives.

The findings of the two studies suggest that suicide prevention and intervention efforts geared at teens and young adults should employ social networking and other types of technology, researchers say.

“Obviously this is a place where adolescents are expressing their feelings,” said Scottye Cash, associate professor of social work at The Ohio State University and lead author of the studies. “It leads me to believe that we need to think about using social media as an intervention and as a way to connect with people.”

The research team is in the process conducting a study similar to the MySpace analysis by examining young people’s Twitter messages for suicidal content. The researchers would like to analyze Facebook, but too few of the profiles are public, Cash said.

Suicide is the third leading cause of death among youths between the ages of 10 and 24 years, according to the Centers for Disease Control and Prevention (CDC).

Cash and colleagues published the MySpace research in a recent issue of the journal Cyberpsychology, Behavior and Social Networking. They presented the survey findings at a meeting of the American Academy of Child and Adolescent Psychiatry.

Cash’s interest in this phenomenon was sparked in part by media reports about teenagers using social media to express suicidal thoughts and behaviors.

“We wanted to know: Is that accurate, or are these isolated incidents? We found that in a short period of time, there were dozens of examples of teens with suicidal thoughts using MySpace to talk to their friends,” she said.

The researchers performed a content analysis of public profiles on MySpace. They downloaded profile pages of a 41,000-member sample of 13- to 24-year-olds from March 3-4, 2008, and again in December 2008, this time with comments included. By developing a list of phrases to identify potential suicidal thoughts or behaviors, the researchers narrowed 2 million downloaded comments to 1,083 that contained suggestions of suicidality, and used a manual process to eventually arrive at 64 posts that were clear discussions of suicide.

“There’s a lot of drama and angst in teenagers so in a lot of cases, they might say something ‘will kill them’ but not really mean it. Teasing out that hyperbole was an intense process,” Cash said. Song lyrics also made up a surprising number of references to suicide, she added.

The three most common phrases within the final sample were “kill myself” (51.6 percent), “want to die” (15.6 percent) and “suicide” (14.1 percent). Though in more than half of the posts the context was unknown, Cash and colleagues determined that 42 percent of the posts referred to problems with family or other relationships – including 15.6 percent that were about break-ups – and 6.3 percent were attributable to mental health problems or substance abuse.

Very few of the posts identified the method the adolescents would consider in a suicide attempt, but 3 percent mentioned guns, 1.6 percent referred to a knife and 1.6 percent combined being hit by a car and a knife.

With this information in hand, Cash and co-investigator Jeffrey Bridge of the Research Institute at Nationwide Children’s Hospital surveyed young people to learn more about how they convey their depression and suicidal thoughts. Bridge also co-authored the MySpace paper.

Collaborating with Research Now, a social marketing firm, the researchers obtained a sample of survey participants through a company that collects consumer opinions. The final sample included 1,089 participants age 18-24 with an average age of almost 21, half male and half female, and 70.6 percent white.

They were asked about their history of suicidal thoughts and attempts, general Internet and technology use, social networking activity and whether they had symptoms of depression.

More than a third reported they have had suicidal thoughts; of those, 37.5 percent had attempted suicide, resulting in a 13 percent rate of suicide attempts among the entire sample. That figure compares to the 8 percent of U.S. high-school students who reported in a 2011 CDC national survey that they had attempted suicide at least once in the previous year. According to that survey, almost 16 percent of youths had seriously considered suicide and almost 13 percent had made a suicide plan in the previous 12 months.

Results of Cash’s survey showed that respondents would favor talking to a friend or family member when they were depressed, followed by sending texts, talking on the phone, using instant messaging and posting to a social networking site. Less common responses included talking to a health-care provider, posting to a blog, calling a suicide prevention hotline and posting to an online suicide support group.

Response trends suggested, though, that participants with suicidal thoughts or attempts were more willing to use technology – specifically the phone, instant messaging, texting and social networking – to reach out compared to those with no suicidal history. In light of this trend, the fact that the participants were active online consumers might have contributed to the relatively high percentage of suicide attempts among the study sample. In addition, the survey also asked about lifetime suicide history, not just recent history, Cash noted.

The survey also showed that this age group looks to the Internet for information on sensitive topics, and again suggested that young adults of both sexes with a history of suicidal thoughts or attempts consulted the Internet for information about topics that are difficult to discuss – specifically drug use, sex, depression, eating disorders or other mental health concerns. Females with past suicide attempts used social networking the most, according to the results.

“It appears that our methods of reaching out to adolescents and young adults is not actually meeting them where they are. If, as adults, we’re saying, ‘this is what we think you need’ and they tell us they’re not going to use it, should we keep pumping resources into suicide hotlines?” Cash said. “We need to find new ways to connect with them and help them with whatever they’re struggling with, or, in other words, meet them where they are in ways that make sense to them.”

A notable resource already available is www.reachout.com, a website geared toward adolescents who are struggling through a tough time. Some Internet-based resources exist that could serve as models for new suicide prevention interventions, she noted. They include teen.smokefree.gov and www.thatsnotcool.com

The survey research was supported by an Ohio State University College of Social Work Seed Grant.

Additional co-authors of the MySpace paper include Michael Thelwall of the University of Wolverhampton in the United Kingdom, Sydney Peck of Elmira College and Jared Ferrell of the University of Akron.

#

Contact: Scottye Cash, Cash.33@osu.edu (Email is the best way to reach Cash.)

Written by Emily Caldwell, (614) 292-8310; Caldwell.151@osu.edu

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More data storage? Here's how to fit 1,000 terabytes on a DVD

More data storage? Here's how to fit 1,000 terabytes on a DVD

  1:17:00 AM    Science Lover

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We live in a world where digital information is exploding. Some 90% of the world's data was generated in the past two years. The obvious question is: how can we store it all?

Using nanotechnology, researchers have developed a technique to increase the data storage capacity of a DVD from a measly 4.7GB to 1,000TB. Credit: Nature Communications

In Nature Communications today, we, along with Richard Evans from CSIRO, show how we developed a new technique to enable the data capacity of a single DVD to increase from 4.7 gigabytes up to one petabyte (1,000 terabytes). This is equivalent of 10.6 years of compressed high-definition video or 50,000 full high-definition movies.

So how did we manage to achieve such a huge boost in data storage? First, we need to understand how data is stored on optical discs such as CDs and DVDs.

The basics of digital storage

Although optical discs are used to carry software, films, games, and private data, and have great advantages over other recording media in terms of cost, longevity and reliability, their low data storage capacity is their major limiting factor.

The operation of optical data storage is rather simple. When you burn a CD, for example, the information is transformed to strings of binary digits (0s and 1s, also called bits). Each bit is then laser "burned" into the disc, using a single beam of light, in the form of dots.

The storage capacity of optical discs is mainly limited by the physical dimensions of the dots. But as there's a limit to the size of the disc as well as the size of the dots, many current methods of data storage, such as DVDs and Blu-ray discs, continue to have low level storage density.

To get around this, we had to look at light's fundamental laws.
On the basis of this law, the diameter of a spot of light, obtained by focusing a light beam through a lens, cannot be smaller than half its wavelength – around 500 nanometres (500 billionths of a metre) for visible light.

And while this law plays a huge role in modern optical microscopy, it also sets up a barrier for any efforts from researchers to produce extremely small dots – in the nanometre region – to use as binary bits.

In our study, we showed how to break this fundamental limit by using a two-light-beam method, with different colours, for recording onto discs instead of the conventional single-light-beam method.

Both beams must abide by Abbe's law, so they cannot produce smaller dots individually. But we gave the two beams different functions:

• The first beam (red, in the figure right) has a round shape, and is used to activate the recording. We called it the writing beam
• The second beam – the purple donut-shape – plays an anti-recording function, inhibiting the function of the writing beam

The two beams were then overlapped. As the second beam cancelled out the first in its donut ring, the recording process was tightly confined to the centre of the writing beam.

This new technique produces an effective focal spot of nine nanometres – or one ten thousandth the diameter of a human hair.

The technique, in practical terms

Our work will greatly impact the development of super-compact devices as well as nanoscience and nanotechnology research.

The exceptional penetration feature of light beams allow for 3D recording or fabrication, which can dramatically increase the data storage – the number of dots – on a single optical device.

The technique is also cost-effective and portable, as only conventional optical and laser elements are used, and allows for the development of optical data storage with long life and low energy consumption, which could be an ideal platform for a Big Data centre.

As the rate of information generated worldwide continues to accelerate, the aim of more storage capacity in compact devices will continue. Our breakthrough has put that target within our reach.

 

More information: www.nature.com/ncomms/2013/130619/ncomms3061/full/ncomms3061.html 

 

Story from: http://phys.org/news/2013-06-storage-terabytes-dvd.html#ajTabs

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The Link Between Circadian Rhythms and Aging: Gene Associated With Longevity Also Regulates the Body's Circadian Clock

The Link Between Circadian Rhythms and Aging: Gene Associated With Longevity Also Regulates the Body's Circadian Clock

  12:39:00 AM    Science Lover

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Human sleeping and waking patterns are largely governed by an internal circadian clock that corresponds closely with the 24-hour cycle of light and darkness. This circadian clock also controls other body functions, such as metabolism and temperature regulation.

A new study finds that a gene associated with longevity also regulates the body’s circadian clock. (Credit: iStockphoto)

Studies in animals have found that when that rhythm gets thrown off, health problems including obesity and metabolic disorders such as diabetes can arise. Studies of people who work night shifts have also revealed an increased susceptibility to diabetes.

A new study from MIT shows that a gene called SIRT1, previously shown to protect against diseases of aging, plays a key role in controlling these circadian rhythms. The researchers found that circadian function decays with aging in normal mice, and that boosting their SIRT1 levels in the brain could prevent this decay. Conversely, loss of SIRT1 function impairs circadian control in young mice, mimicking what happens in normal aging.

Since the SIRT1 protein itself was found to decline with aging in the normal mice, the findings suggest that drugs that enhance SIRT1 activity in humans could have widespread health benefits, says Leonard Guarente, the Novartis Professor of Biology at MIT and senior author of a paper describing the findings in the June 20 issue of Cell.

"If we could keep SIRT1 as active as possible as we get older, then we'd be able to retard aging in the central clock in the brain, and health benefits would radiate from that," Guarente says.

Staying on schedule

In humans and animals, circadian patterns follow a roughly 24-hour cycle, directed by the circadian control center of the brain, called the suprachiasmatic nucleus (SCN), located in the hypothalamus.

"Just about everything that takes place physiologically is really staged along the circadian cycle," Guarente says. "What's now emerging is the idea that maintaining the circadian cycle is quite important in health maintenance, and if it gets broken, there's a penalty to be paid in health and perhaps in aging."

Last year, Guarente found that a robust circadian period correlated with longer lifespan in mice. That got him wondering what role SIRT1, which has been shown to prolong lifespan in many animals, might play in that phenomenon. SIRT1, which Guarente first linked with aging more than 15 years ago, is a master regulator of cell responses to stress, coordinating a variety of hormone networks, proteins and genes to help keep cells alive and healthy.

To investigate SIRT1's role in circadian control, Guarente and his colleagues created genetically engineered mice that produce different amounts of SIRT1 in the brain. One group of mice had normal SIRT1 levels, another had no SIRT1, and two groups had extra SIRT1 -- either twice or 10 times as much as normal.

Mice lacking SIRT1 had slightly longer circadian cycles (23.9 hours) than normal mice (23.6 hours), and mice with a 10-fold increase in SIRT1 had shorter cycles (23.1 hours).

In mice with normal SIRT1 levels, the researchers confirmed previous findings that when the 12-hour light/dark cycle is interrupted, younger mice readjust their circadian cycles much more easily than older ones. However, they showed for the first time that mice with extra SIRT1 do not suffer the same decline in circadian control as they age.

The researchers also found that SIRT1 exerts this control by regulating the genes BMAL and CLOCK, the two major keepers of the central circadian clock.

Enhancing circadian function

A growing body of evidence suggests that being able to respond to large or small disruptions of the light/dark cycle is important to maintaining healthy metabolic function, Guarente says.

"Essentially we experience a mini jet lag every day because the light cycle is constantly changing. The critical thing for us is to be able to adapt smoothly to these jolts," Guarente says. "Many studies in mice say that while young mice do this perfectly well, it's the old mice that have the problem. So that could well be true in humans."

If so, it could be possible to treat or prevent diseases of aging by enhancing circadian function -- either by delivering SIRT1 activators in the brain or developing drugs that enhance another part of the circadian control system, Guarente says.

"I think we should look at every aspect of the machinery of the circadian clock in the brain, and any intervention that can maintain that machinery with aging ought to be good," he says. "One entry point would be SIRT1, because we've shown in mice that genetic maintenance of SIRT1 helps maintain circadian function."

Some SIRT1 activators are now being tested against diabetes, inflammation and other diseases, but they are not designed to cross the blood-brain barrier and would likely not be able to reach the SCN. However, Guarente believes it could be possible to design SIRT1 activators that can get into the brain.

Roman Kondratov, an associate professor of biology at Cleveland State University, says the study raises several exciting questions regarding the potential to delay or reverse age-related changes in the brain through rejuvenation of the circadian clock with SIRT1 enhancement.

"The importance of this study is that it has both basic and potentially translational applications, taking into account the fact that pharmacological modulators of SIRT1 are currently under active study," Kondratov says.

Researchers in Guarente's lab are now investigating the relationship between health, circadian function and diet. They suspect that high-fat diets might throw the circadian clock out of whack, which could be counteracted by increased SIRT1 activation.

The research was funded by the National Institutes of Health and the Glenn Foundation for Medical Research.

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A Robot That Runs Like a Cat

A Robot That Runs Like a Cat

  8:22:00 AM    Science Lover

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Thanks to its legs, whose design faithfully reproduces feline morphology, EPFL's four-legged "cheetah-cub robot" has the same advantages as its model: it is small, light and fast. Still in its experimental stage, the robot will serve as a platform for research in locomotion and biomechanics.

This is cheetah-cub, a compliant quadruped robot.
(Credit: (c) EPFL)

Even though it doesn't have a head, you can still tell what kind of animal it is: the robot is definitely modeled upon a cat. Developed by EPFL's Biorobotics Laboratory (Biorob), the "cheetah-cub robot," a small-size quadruped prototype robot, is described in an article appearing today in the International Journal of Robotics Research. The purpose of the platform is to encourage research in biomechanics; its particularity is the design of its legs, which make it very fast and stable. Robots developed from this concept could eventually be used in search and rescue missions or for exploration.

This robot is the fastest in its category, namely in normalized speed for small quadruped robots under 30Kg. During tests, it demonstrated its ability to run nearly seven times its body length in one second. Although not as agile as a real cat, it still has excellent auto-stabilization characteristics when running at full speed or over a course that included disturbances such as small steps. In addition, the robot is extremely light, compact, and robust and can be easily assembled from materials that are inexpensive and readily available. 

Faithful reproduction

The machine's strengths all reside in the design of its legs. The researchers developed a new model with this robot, one that is based on the meticulous observation and faithful reproduction of the feline leg. The number of segments -- three on each leg -- and their proportions are the same as they are on a cat. Springs are used to reproduce tendons, and actuators -- small motors that convert energy into movement -- are used to replace the muscles.

"This morphology gives the robot the mechanical properties from which cats benefit, that's to say a marked running ability and elasticity in the right spots, to ensure stability," explains Alexander Sprowitz, a Biorob scientist. "The robot is thus naturally more autonomous."

Sized for a search

According to Biorob director Auke Ijspeert, this invention is the logical follow-up of research the lab has done into locomotion that included a salamander robot and a lamprey robot. "It's still in the experimental stages, but the long-term goal of the cheetah-cub robot is to be able to develop fast, agile, ground-hugging machines for use in exploration, for example for search and rescue in natural disaster situations. Studying and using the principles of the animal kingdom to develop new solutions for use in robots is the essence of our research."

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New Layer of the Human Cornea Discovered

New Layer of the Human Cornea Discovered

  10:24:00 AM    Science Lover

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Scientists at The University of Nottingham have discovered a previously undetected layer in the cornea, the clear window at the front of the human eye.

Scientists have discovered a previously undetected layer in the cornea, the clear window at the front of the human eye. (Credit: © Kesu / Fotolia)

The breakthrough, announced in a study published in the academic journal Ophthalmology, could help surgeons to dramatically improve outcomes for patients undergoing corneal grafts and transplants.

The new layer has been dubbed the Dua's Layer after the academic Professor Harminder Dua who discovered it.

Professor Dua, Professor of Ophthalmology and Visual Sciences, said: "This is a major discovery that will mean that ophthalmology textbooks will literally need to be re-written. Having identified this new and distinct layer deep in the tissue of the cornea, we can now exploit its presence to make operations much safer and simpler for patients.

"From a clinical perspective, there are many diseases that affect the back of the cornea which clinicians across the world are already beginning to relate to the presence, absence or tear in this layer."

The human cornea is the clear protective lens on the front of the eye through which light enters the eye. Scientists previously believed the cornea to be composed of five layers, from front to back, the corneal epithelium, Bowman's layer, the corneal stroma, Descemet's membrane and the corneal endothelium.

The new layer that has been discovered is located at the back of the cornea between the corneal stroma and Descemet's membrane. Although it is just 15 microns thick -- the entire cornea is around 550 microns thick or 0.5mm -- it is incredibly tough and is strong enough to be able to withstand one and a half to two bars of pressure.

The scientists proved the existence of the layer by simulating human corneal transplants and grafts on eyes donated for research purposes to eye banks located in Bristol and Manchester.

During this surgery, tiny bubbles of air were injected into the cornea to gently separate the different layers. The scientists then subjected the separated layers to electron microscopy, allowing them to study them at many thousand times their actual size.

Understanding the properties and location of the new Dua's layer could help surgeons to better identify where in the cornea these bubbles are occurring and take appropriate measures during the operation. If they are able to inject a bubble next to the Dua's layer, its strength means that it is less prone to tearing, meaning a better outcome for the patient.

The discovery will have an impact on advancing understanding of a number of diseases of the cornea, including acute hydrops, Descematocele and pre-Descemet's dystrophies.

The scientists now believe that corneal hydrops, a bulging of the cornea caused by fluid build up that occurs in patients with keratoconus (conical deformity of the cornea), is caused by a tear in the Dua layer, through which water from inside the eye rushes in and causes waterlogging. 

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New Light On Possible 'Fifth Force of Nature'

New Light On Possible 'Fifth Force of Nature'

  7:52:00 PM    Science Lover

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In a breakthrough for the field of particle physics, Professor of Physics Larry Hunter and colleagues at Amherst College and The University of Texas at Austin have established new limits on what scientists call "long-range spin-spin interactions" between atomic particles. These interactions have been proposed by theoretical physicists but have not yet been seen. Their observation would constitute the discovery of a "fifth force of nature" (in addition to the four known fundamental forces: gravity, weak, strong and electromagnetic) and would suggest the existence of new particles, beyond those presently described by the Standard Model of particle physics.

This picture depicts the long-range spin-spin interaction (blue wavy lines) in which the spin-sensitive detector on Earth’s surface interacts with geoelectrons (red dots) deep in Earth’s mantle. The arrows on the geoelectrons indicate their spin orientations, opposite that of Earth’s magnetic field lines (white arcs). (Credit: Illustration: Marc Airhart (University of Texas at Austin) and Steve Jacobsen (Northwestern University).)

The new limits were established by considering the interaction between the spins of laboratory fermions (electrons, neutrons and protons) and the spins of the electrons within Earth. To make this study possible, the authors created the first comprehensive map of electron polarization within Earth induced by the planet's geomagnetic field.

Hunter -- along with emeritus Amherst physics professor Joel Gordon; postdoctoral fellow Stephen Peck; student researcher Daniel Ang '15; and Jung-Fu "Afu" Lin, associate professor of geosciences at UT Austin -- co-authored a paper about their work that appears in this week's issue of the journal Science. The highly interdisciplinary research relies on geophysics, atomic physics, particle physics, mineral physics, solid-state physics and nuclear physics to reach its conclusions.

The paper describes how the team combined a model of Earth's interior with a precise map of the planet's geomagnetic field to produce a map of the magnitude and direction of electron spins throughout Earth. Their model was based in part on insights gained from Lin's studies of spin transitions at the high temperatures and pressures of Earth's interior.

Every fundamental particle (every electron, neutron and proton, to be specific), explained Hunter, has the intrinsic atomic property of "spin." Spin can be thought of as a vector -- an arrow that points in a particular direction. Like all matter, Earth and its mantle -- a thick geological layer sandwiched between the thin outer crust and the central core -- are made of atoms. The atoms are themselves made up of electrons, neutrons and protons that have spin. Earth's magnetic field causes some of the electrons in the mantle's minerals to become slightly spin-polarized, meaning the directions in which their spins point are no longer completely random, but have some net orientation.

Earlier experiments, including one in Hunter's laboratory, explored whether their laboratory spins prefer to point in a particular direction. "We know, for example, that a magnetic dipole has a lower energy when it is oriented parallel to the geomagnetic field and it lines up with this particular direction -- that is how a compass works," he explained. "Our experiments removed this magnetic interaction and looked to see if there might be some other interaction that would orient our experimental spins. One interpretation of this 'other' interaction is that it could be a long-range interaction between the spins in our apparatus, and the electron spins within the Earth, that have been aligned by the geomagnetic field. This is the long-range spin-spin interaction we are looking for."

So far, no experiment has been able to detect any such interaction. But in Hunter's paper, the researchers describe how they were able to infer that such so-called spin-spin forces, if they exist, must be incredibly weak -- as much as a million times weaker than the gravitational attraction between the particles. At this level, the experiments can constrain "torsion gravity" -- a proposed theoretical extension of Einstein's Theory of General Relativity. Given the high sensitivity of the technique Hunter and his team used, it may provide a useful path for future experiments that will refine the search for such a fifth force. If a long-range spin-spin force is found, it not only would revolutionize particle physics but might eventually provide geophysicists with a new tool that would allow them to directly study the spin-polarized electrons within Earth.

"If the long-range spin-spin interactions are discovered in future experiments, geoscientists can eventually use such information to reliably understand the geochemistry and geophysics of the planet's interior," said Lin.

Possible future discoveries aside, Hunter said that he was pleased that this particular project enabled him to work with Lin. "When I began investigating spin transitions in the mantle, all of the literature led to him," he explained. "I was thrilled that he was interested in the project and willing to sign on as a collaborator. He has been a good teacher and has had enormous patience with my ignorance about geophysics. It has been a very fruitful collaboration."

Lin had his own take: "The most rewarding and surprising thing about this project was realizing that particle physics could actually be used to study the deep Earth."

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Human Evolution Driven By Changing Environment

Human Evolution Driven By Changing Environment

  9:46:00 AM    Science Lover

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A series of rapid environmental changes in East Africa roughly 2 million years ago may be responsible for driving human evolution, according to researchers at Penn State and Rutgers University.

The researchers examined lake sediments from Olduvai Gorge in northern Tanzania, looking for biomarkers -- fossil molecules -- from ancient trees and grasses. (Credit: Gail Ashley)

"The landscape early humans were inhabiting transitioned rapidly back and forth between a closed woodland and an open grassland about five to six times during a period of 200,000 years," said Clayton Magill, graduate student in geosciences at Penn State. "These changes happened very abruptly, with each transition occurring over hundreds to just a few thousand years."

According to Katherine Freeman, professor of geosciences, Penn State, the current leading hypothesis suggests that evolutionary changes among humans during the period the team investigated were related to a long, steady environmental change or even one big change in climate.

"There is a view this time in Africa was the 'Great Drying,' when the environment slowly dried out over 3 million years," she said. "But our data show that it was not a grand progression towards dry; the environment was highly variable."

According to Magill, many anthropologists believe that variability of experience can trigger cognitive development.

"Early humans went from having trees available to having only grasses available in just 10 to 100 generations, and their diets would have had to change in response," he said. "Changes in food availability, food type, or the way you get food can trigger evolutionary mechanisms to deal with those changes. The result can be increased brain size and cognition, changes in locomotion and even social changes -- how you interact with others in a group. Our data are consistent with these hypotheses. We show that the environment changed dramatically over a short time, and this variability coincides with an important period in our human evolution when the genus Homo was first established and when there was first evidence of tool use."

The researchers -- including Gail Ashley, professor of earth and planetary sciences, Rutgers University -- examined lake sediments from Olduvai Gorge in northern Tanzania. They removed the organic matter that had either washed or was blown into the lake from the surrounding vegetation, microbes and other organisms 2 million years ago from the sediments. In particular, they looked at biomarkers -- fossil molecules from ancient organisms -- from the waxy coating on plant leaves.

"We looked at leaf waxes because they're tough, they survive well in the sediment," said Freeman.

The team used gas chromatography and mass spectrometry to determine the relative abundances of different leaf waxes and the abundance of carbon isotopes for different leaf waxes. The data enabled them to reconstruct the types of vegetation present in the Olduvai Gorge area at very specific time intervals.

The results showed that the environment transitioned rapidly back and forth between a closed woodland and an open grassland.

To find out what caused this rapid transitioning, the researchers used statistical and mathematical models to correlate the changes they saw in the environment with other things that may have been happening at the time, including changes in the Earth's movement and changes in sea-surface temperatures.

"The orbit of the Earth around the sun slowly changes with time," said Freeman. "These changes were tied to the local climate at Olduvai Gorge through changes in the monsoon system in Africa. Slight changes in the amount of sunshine changed the intensity of atmospheric circulation and the supply of water. The rain patterns that drive the plant patterns follow this monsoon circulation. We found a correlation between changes in the environment and planetary movement."

The team also found a correlation between changes in the environment and sea-surface temperature in the tropics.

"We find complementary forcing mechanisms: one is the way Earth orbits, and the other is variation in ocean temperatures surrounding Africa," Freeman said. The researchers recently published their results in the Proceedings of the National Academy of Sciences along with another paper in the same issue that builds on these findings. The second paper shows that rainfall was greater when there were trees around and less when there was a grassland.

"The research points to the importance of water in an arid landscape like Africa," said Magill. "The plants are so intimately tied to the water that if you have water shortages, they usually lead to food insecurity.

"Together, these two papers shine light on human evolution because we now have an adaptive perspective. We understand, at least to a first approximation, what kinds of conditions were prevalent in that area and we show that changes in food and water were linked to major evolutionary changes."

The National Science Foundation funded this research.

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Sound Beam Could One Day Be Invisible Scalpel

Sound Beam Could One Day Be Invisible Scalpel

  4:34:00 PM    Science Lover

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A carbon-nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.

With a new technique that uses tightly-focused sound waves for micro-surgery, University of Michigan engineering researchers drilled a 150-micrometer hole in a confetti-sized artificial kidney stone. (Credit: Hyoung Won Baac)

Today's ultrasound technology enables far more than glimpses into the womb. Doctors routinely use focused sound waves to blast apart kidney stones and prostate tumors, for example. The tools work primarily by focusing sound waves tightly enough to generate heat, says Jay Guo, a professor of electrical engineering and computer science, mechanical engineering, and macromolecular science and engineering. Guo is a co-author of a paper on the new technique published in the current issue of Nature's journal Scientific Reports.

The beams that today's technology produces can be unwieldy, says Hyoung Won Baac, a research fellow at Harvard Medical School who worked on this project as a doctoral student in Guo's lab.

"A major drawback of current strongly focused ultrasound technology is a bulky focal spot, which is on the order of several millimeters," Baac said. "A few centimeters is typical. Therefore, it can be difficult to treat tissue objects in a high-precision manner, for targeting delicate vasculature, thin tissue layer and cellular texture. We can enhance the focal accuracy 100-fold."

The team was able to concentrate high-amplitude sound waves to a speck just 75 by 400 micrometers (a micrometer is one-thousandth of a millimeter). Their beam can blast and cut with pressure, rather than heat. Guo speculates that it might be able to operate painlessly because its beam is so finely focused it could avoid nerve fibers. The device hasn't been tested in animals or humans yet, though.

"We believe this could be used as an invisible knife for noninvasive surgery," Guo said. "Nothing pokes into your body, just the ultrasound beam. And it is so tightly focused, you can disrupt individual cells."

To achieve this superfine beam, Guo's team took an optoacoustic approach that converts light from a pulsed laser to high-amplitude sound waves through a specially designed lens. The general technique has been around since Thomas Edison's time. It has advanced over the centuries, but for medical applications today, the process doesn't normally generate a sound signal strong enough to be useful.

The U-M researchers' system is unique because it performs three functions: it converts the light to sound, focuses it to a tiny spot and amplifies the sound waves. To achieve the amplification, the researchers coated their lens with a layer of carbon nanotubes and a layer of a rubbery material called polydimethylsiloxane. The carbon nanotube layer absorbs the light and generates heat from it. Then the rubbery layer, which expands when exposed to heat, drastically boosts the signal by the rapid thermal expansion.

The resulting sound waves are 10,000 times higher frequency than humans can hear. They work in tissues by creating shockwaves and microbubbles that exert pressure toward the target, which Guo envisions could be tiny cancerous tumors, artery-clogging plaques or single cells to deliver drugs. The technique might also have applications in cosmetic surgery.

In experiments, the researchers demonstrated micro ultrasonic surgery, accurately detaching a single ovarian cancer cell and blasting a hole less than 150 micrometers in an artificial kidney stone in less than a minute.

"This is just the beginning," Guo said. "This work opens a way to probe cells or tissues in much smaller scale."

The researchers will present the work at the SPIE Photonics West meeting in San Francisco. The research was funded by the National Science Foundation and the National Institutes of Health.

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'Invisibility': Key to Better Electronics?

'Invisibility': Key to Better Electronics?

  11:07:00 AM    Science Lover

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Visual 'Cloaking' Technology Enables More Efficient Transfer of Electrons

 A new approach that allows objects to become "invisible" has now been applied to an entirely different area: letting particles "hide" from passing electrons, which could lead to more efficient thermoelectric devices and new kinds of electronics.

Diagram shows the 'probability flux' of electrons, a 
representation of the paths of electrons as they pass through 
an 'invisible' nanoparticle. While the paths are bent as 
they enter the particle, they are subsequently bent back 
so that they re-emerge from the other side on the same 
trajectory they started with — just as if the particle 
wasn't there. (Credit: Image courtesy Bolin Liao et al.)

The concept -- developed by MIT graduate student Bolin Liao, former postdoc Mona Zebarjadi (now an assistant professor at Rutgers University), research scientist Keivan Esfarjani, and mechanical engineering professor Gang Chen -- is described in a paper in the journal Physical Review Letters.

Normally, electrons travel through a material in a way that is similar to the motion of electromagnetic waves, including light; their behavior can be described by wave equations. That led the MIT researchers to the idea of harnessing the cloaking mechanisms developed to shield objects from view -- but applying it to the movement of electrons, which is key to electronic and thermoelectric devices.

Previous work on cloaking objects from view has relied on so-called metamaterials made of artificial materials with unusual properties. The composite structures used for cloaking cause light beams to bend around an object and then meet on the other side, resuming their original path -- making the object appear invisible.

"We were inspired by this idea," says Chen, the Carl Richard Soderberg Professor of Power Engineering at MIT, who decided to study how it might apply to electrons instead of light. But in the new electron-cloaking material developed by Chen and his colleagues, the process is slightly different.

The MIT researchers modeled nanoparticles with a core of one material and a shell of another. But in this case, rather than bending around the object, the electrons do actually pass through the particles: Their paths are bent first one way, then back again, so they return to the same trajectory they began with.

In computer simulations, the concept appears to work, Liao says. Now, the team will try to build actual devices to see whether they perform as expected. "This was a first step, a theoretical proposal," Liao says. "We want to carry on further research on how to make some real devices out of this strategy."

While the initial concept was developed using particles embedded in a normal semiconductor substrate, the MIT researchers would like to see if the results can be replicated with other materials, such as two-dimensional sheets of graphene, which might offer interesting additional properties.

The MIT researchers' initial impetus was to optimize the materials used in thermoelectric devices, which produce an electrical current from a temperature gradient. Such devices require a combination of characteristics that are hard to obtain: high electrical conductivity (so the generated current can flow freely), but low thermal conductivity (to maintain a temperature gradient). But the two types of conductivity tend to coexist, so few materials offer these contradictory characteristics. The team's simulations show this electron-cloaking material could meet these requirements unusually well.

The simulations used particles a few nanometers in size, matching the wavelength of flowing electrons and improving the flow of electrons at particular energy levels by orders of magnitude compared to traditional doping strategies. This might lead to more efficient filters or sensors, the researchers say. As the components on computer chips get smaller, Chen says, "we have to come up with strategies to control electron transport," and this might be one useful approach.

The concept could also lead to a new kind of switches for electronic devices, Chen says. The switch could operate by toggling between transparent and opaque to electrons, thus turning a flow of them on and off. "We're really just at the beginning," he says. "We're not sure how far this is going to go yet, but there is some potential" for significant applications.

Xiang Zhang, a professor of mechanical engineering at the University of California at Berkeley who was not involved in this research, says "this is very exciting work" that expands the concept of cloaking to the domain of electrons. The authors, he says, "uncovered a very interesting approach that may be very useful to thermoelectric applications."

This research was funded by the U.S. Department of Energy (DOE) through MIT's Solid-State Solar-Thermal Energy Conversion center, a DOE Energy Frontier Research Center.

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