BTemplates.com

Powered by Blogger.

Pageviews past week

Quantum mechanics

Auto News

artificial intelligence

About Me

Recommend us on Google!

Information Technology

Popular Posts

Showing posts with label Lund University. Show all posts
Showing posts with label Lund University. Show all posts

Thursday, June 23, 2011

Cutting Edge Training Developed the Human Brain 80,000 Years Ago



Advanced crafting of stone spearheads contributed to the development of new ways of human thinking and behaving, according to new findings by archaeologists from Lund University. The technology took a long time to acquire, required step by step planning and increased social interaction across the generations. This led to the human brain developing new abilities.
Cave in South Africa where excavations have taken 
place. (Credit: Image courtesy of Lund University)

Some 200,000 years ago, small groups of people wandered across Africa, looking anatomically much like present-day humans, but not thinking the way we do today. Studies of fossils and the rate of mutations in DNA show that the human species to which we all belong -- Homo sapiens sapiens -- has existed for 200,000 years.

But the archaeological research of recent years has shown that, even though the most ancient traces of modern humans are 200,000 years old, the development of modern cognitive behaviour is probably much younger. For about 100,000 years, there were people who looked like us, but who were cognitively and socially very different from us.



It is precisely that period of transformation that the researchers at Lund University in Sweden have studied. In the next issue of the Journal of Human Evolution, they present new findings on the early modern humans that existed in what is now South Africa, approximately 80,000 years ago.

The findings show that people at that time used advanced technology for the production of spearheads and that the complicated crafting process likely developed the working memory and social life of humans.

"When the technology was passed from one generation to the next, from adults to children, it became part of a cultural learning process which created a socially more advanced society than before. This affected the development of the human brain and cognitive ability," says Anders Högberg, PhD.

The technology led to increased social interaction within and across the generations. This happened because the crafting of stone spearheads took a long time to learn and required a lot of knowledge, both theoretical and practical. Producing a stone spearhead also required the ability to plan in several stages. This social learning contributed to the subsequent development of early modern humans' cognitive ability to express symbolism and abstract thoughts through their material culture, for example in the form of decorated objects.

"The excavations have been carried out in a small cave; the location we have studied is called Hollow Rock Shelter and lies 250 km north of Cape Town. We are cooperating with the University of Cape Town and the research we have just published is part of a larger research project on this location," says Professor Lars Larsson.

Friday, June 10, 2011

New genetic technique converts skin cells into brain cells



A research breakthrough has proven that it is possible to reprogram mature cells from human skin directly into brain cells, without passing through the stem cell stage. The unexpectedly simple technique involves activating three genes in the skin cells; genes which are already known to be active in the formation of brain cells at the foetal stage.
converts skin cells into brain cells

The new technique avoids many of the ethical dilemmas that stem cell research has faced.

For the first time, a research group at Lund University in Sweden has succeeded in creating specific types of nerve cells from human skin. By reprogramming connective tissue cells, called fibroblasts, directly into nerve cells, a new field has been opened up with the potential to take research on cell transplants to the next level. The discovery represents a fundamental change in the view of the function and capacity of mature cells. By taking mature cells as their starting point instead of stem cells, the Lund researchers also avoid the ethical issues linked to research on embryonic stem cells.

Head of the research group Malin Parmar was surprised at how receptive the fibroblasts were to new instructions.

"We didn't really believe this would work, to begin with it was mostly just an interesting experiment to try. However, we soon saw that the cells were surprisingly receptive to instructions."

The study, which was published in the latest issue of the scientific journal PNAS, also shows that the skin cells can be directed to become certain types of nerve cells.

In experiments where a further two genes were activated, the researchers have been able to produce dopamine brain cells, the type of cell which dies in Parkinson's disease. The research findings are therefore an important step towards the goal of producing nerve cells for transplant which originate from the patients themselves. The cells could also be used as disease models in research on various neurodegenerative diseases.

Unlike older reprogramming methods, where skin cells are turned into pluripotent stem cells, known as IPS cells, direct reprogramming means that the skin cells do not pass through the stem cell stage when they are converted into nerve cells. Skipping the stem cell stage probably eliminates the risk of tumours forming when the cells are transplanted. Stem cell research has long been hampered by the propensity of certain stem cells to continue to divide and form tumours after being transplanted.

Before the direct conversion technique can be used in clinical practice, more research is needed on how the new nerve cells survive and function in the brain. The vision for the future is that doctors will be able to produce the brain cells that a patient needs from a simple skin or hair sample. In addition, it is presumed that specifically designed cells originating from the patient would be accepted better by the body's immune system than transplanted cells from donor tissue.

"This is the big idea in the long run. We hope to be able to do a biopsy on a patient, make dopamine cells, for example, and then transplant them as a treatment for Parkinson's disease", says Malin Parmar, who is now continuing the research to develop more types of brain cells using the new technique.

More information: 'Direct conversion of human fibroblasts to dopaminergic neurons', publ. PNAS 2011; 6 June 2011: http://www.pnas.or … 108.abstract

Provided by Lund University
Enhanced by Zemanta