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Showing posts with label Harvard School of Public Health. Show all posts
Showing posts with label Harvard School of Public Health. Show all posts

Wednesday, June 15, 2011

Prolonged TV Viewing Linked to Health Risks



Watching television is the most common daily activity apart from work and sleep in many parts of the world, but it is time for people to change their viewing habits. According to a new study from Harvard School of Public Health (HSPH) researchers, prolonged TV viewing was associated with increased risk of type 2 diabetes, cardiovascular disease, and premature death.
New research finds that prolonged TV viewing is 
associated with increased risk of type 2 diabetes, 
cardiovascular disease, and premature death. 
(Credit: © alessandrozocc / Fotolia)

The study appears in the June 15, 2011, edition of the Journal of the American Medical Association.

"The message is simple. Cutting back on TV watching can significantly reduce risk of type 2 diabetes, heart disease, and premature mortality," said senior author Frank Hu, professor of nutrition and epidemiology at HSPH. "We should not only promote increasing physical activity levels but also reduce sedentary behaviors, especially prolonged TV watching," said Hu.

Many people around the world divide their days largely between working, sleeping, and watching television, according to the researchers. Europeans spend an average of 40 percent of their daily free time in front of the television set; Australians, 50 percent. This corresponds to three to four hours of daily viewing -- still less than a reported average of five hours in the U.S. The negative health effects of TV viewing have been documented in prior studies, including associations with reduced physical activity levels and unhealthy diets.



Hu and first author Anders Grøntved, a doctoral student and visiting researcher in the HSPH Department of Nutrition, conducted a meta-analysis, a systematic assessment of all published studies from 1970 to 2011 that linked TV viewing with increased risk of type 2 diabetes, cardiovascular disease, and premature death. Eight large prospective cohort studies from the United States, Europe, and Australia met the researchers' criteria and were included in the meta-analysis.

The results showed that more than two hours of TV viewing per day increased risk of type 2 diabetes and cardiovascular disease, and more than three hours of daily viewing increased risk of premature death. For each additional two hours of TV viewing per day, the risk of type 2 diabetes, cardiovascular disease, and premature mortality increased by 20, 15, and 13 percent respectively. Based on disease incidence in the United States, Hu and Grøntved estimated that among 100,000 individuals per year, each 2-hour increment in TV viewing per day was associated with 176 new cases of type 2 diabetes, 38 new cases of fatal cardiovascular disease, and 104 new cases of all-cause mortality.

Hu and Grøntved found that the effect of prolonged television viewing on type 2 diabetes, which usually occurs in adults, was to some extent explained by the unfavorable influence of TV viewing on obesity. Obesity is related to unhealthy eating habits and low activity levels, major risk factors for both type 2 diabetes and cardiovascular disease.

Limitations to the meta-analysis included the relatively small number of studies and that the assessment of TV viewing was self-reported by participants. In addition, the majority of the studies did not assess the role of diet and physical activity in explaining the adverse effects of TV watching on chronic disease risk.

"Sedentary lifestyle, especially prolonged TV watching, is clearly an important and modifiable risk factor for type 2 diabetes and cardiovascular disease," said Grøntved. "Future research should also look into the effects of extensive use of new media devices on energy balance and chronic disease risk."

Support for the study was provided by the Danish Heart Foundation, Sygekassernes Helsefond (the Danish Health Fund), the Oticon Foundation, the Augustinus Foundation, and the National Institutes of Health.

Friday, April 8, 2011

Coffee Drinking in Your Genes? Genetic Variants in Two Genes Linked With Caffeine Intake


Two genes in which variation affects intake of caffeine, the most widely consumed stimulant in the world, have been discovered. A team of investigators from the National Cancer Institute, Harvard School of Public Health, Brigham and Women's Hospital, and the University of North Carolina at Chapel Hill examined genetic variation across the entire genome of more than 47,000 individuals from the U.S., as described in the open-access journal PLoS Genetics.
Researchers have discovered two genes in which variation 
affects intake of caffeine, the most widely consumed stimulant
in the world. (Credit: iStockphoto/Sergey Galushko)

The genes identified were CYP1A2, which has previously been implicated in the metabolism of caffeine, and AHR, involved in the regulation of CYP1A2. Individuals with the highest-consumption genotype for either gene consumed ~40 mg more caffeine than those with the lowest-consumption genotype, equivalent to the amount of 1/3 cup of caffeinated coffee, or 1 can of cola.

Caffeine is implicated in numerous physiological and medical conditions; it affects sleep patterns, energy levels, mood, and mental and physical performance. The identification of genes that have an impact on daily consumption offers opportunities to better understand these conditions. Further exploration of the identified genetic variants may provide insight into the speed of caffeine metabolism, how long caffeine circulates in the blood, or how strong the physiological effects of consuming a given amount of caffeine are.

Apart from smoking, genetic determinants of lifestyle behaviors have generally not been consistently described. This study is among the first to examine the entire genome for a relationship between genetics and caffeine intake, a lifestyle behavior relevant to over 90% of U.S. adults. The study's success also suggests that additional genetic determinants of dietary and lifestyle behaviors may be identified in the future using a similar genome-based research strategy.


Friday, September 25, 2009

Ancestral Populations Of India And Relationships To Modern Groups Revealed


In a study published in the September 24th issue of Nature, an international team describes how they harnessed modern genomic technology to explore the ancient history of India, the world's second most populous nation.

A map showing the groups across India included in the Nature study. 
(Credit: Photo courtesy of D. Reich, K. Thangaraj, N. Patterson, A. Price and L. Singh)


The new research reveals that nearly all Indians carry genomic contributions from two distinct ancestral populations. Following this ancient mixture, many groups experienced periods of genetic isolation from each other for thousands of years. The study, which has medical implications for people of Indian descent, was led by scientists at the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad, India together with US researchers at Harvard Medical School, the Harvard School of Public Health and the Broad Institute of Harvard and MIT.