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Showing posts with label Alzheimer's Research. Show all posts
Showing posts with label Alzheimer's Research. Show all posts

Saturday, July 16, 2011

Soft Memory Device Opens Door to New Biocompatible Electronics


Researchers from North Carolina State University have developed a memory device that is soft and functions well in wet environments -- opening the door to a new generation of biocompatible electronic devices.
Researchers have created a memory device with the 
physical properties of Jell-O, and that functions well 
in wet environments. (Credit: Michael Dickey, North 
Carolina State University)

"We've created a memory device with the physical properties of Jell-O," says Dr. Michael Dickey, an assistant professor of chemical and biomolecular engineering at NC State and co-author of a paper describing the research.

Conventional electronics are typically made of rigid, brittle materials and don't function well in a wet environment. "Our memory device is soft and pliable, and functions extremely well in wet environments -- similar to the human brain," Dickey says.

Prototypes of the device have not yet been optimized to hold significant amounts of memory, but work well in environments that would be hostile to traditional electronics. The devices are made using a liquid alloy of gallium and indium metals set into water-based gels, similar to gels used in biological research.

The device's ability to function in wet environments, and the biocompatibility of the gels, mean that this technology holds promise for interfacing electronics with biological systems -- such as cells, enzymes or tissue. "These properties may be used for biological sensors or for medical monitoring," Dickey says.



The device functions much like so-called "memristors," which are vaunted as a possible next-generation memory technology. The individual components of the "mushy" memory device have two states: one that conducts electricity and one that does not. These two states can be used to represent the 1s and 0s used in binary language. Most conventional electronics use electrons to create these 1s and 0s in computer chips. The mushy memory device uses charged molecules called ions to do the same thing.

In each of the memory device's circuits, the metal alloy is the circuit's electrode and sits on either side of a conductive piece of gel. When the alloy electrode is exposed to a positive charge it creates an oxidized skin that makes it resistive to electricity. We'll call that the 0. When the electrode is exposed to a negative charge, the oxidized skin disappears, and it becomes conducive to electricity. We'll call that the 1.

Normally, whenever a negative charge is applied to one side of the electrode, the positive charge would move to the other side and create another oxidized skin -- meaning the electrode would always be resistive. To solve that problem, the researchers "doped" one side of the gel slab with a polymer that prevents the formation of a stable oxidized skin. That way one electrode is always conducive -- giving the device the 1s and 0s it needs for electronic memory.

The paper was published online July 4 by Advanced Materials. The paper was co-authored by NC State Ph.D. students Hyung-Jun Koo and Ju-Hee So, and NC State INVISTA Professor of Chemical and Biomolecular Engineering Orlin Velev. The research was supported by the National Science Foundation and the U.S. Department of Energy.

NC State's Department of Chemical and Biomolecular Engineering is part of the university's College of Engineering.

Monday, December 13, 2010

Alzheimer's: 'Cleansing' Brain of Plaques


New molecular tools developed at the University of Michigan show promise for "cleansing" the brain of amyloid plaques, implicated in Alzheimer's disease.
Small Molecules for Metal-Amyloid Species in the Brain. 
(Credit: Mi Hee Lim and Joseph J. Braymer)

A hallmark of Alzheimer's disease -- a neurodegenerative disease with no cure -- is the aggregation of protein-like bits known as amyloid-beta peptides into clumps in the brain called plaques. These plaques and their intermediate messes can cause cell death, leading to the disease's devastating symptoms of memory loss and other mental difficulties.

The mechanisms responsible for the formation of these misfolded proteins and their associations with Alzheimer's disease are not entirely understood, but it's thought that copper and zinc ions are somehow involved.

The research, led by assistant professor Mi Hee Lim, was published online Dec. 3 in the Proceedings of the National Academy of Science.
 
In earlier work, Lim and her team developed dual-purpose molecular tools that both grab metal ions and interact with amyloid-beta. The researchers went on to show that in solutions with or without living cells, the molecules were able to regulate copper-induced amyloid-beta aggregation, not only disrupting the formation of clumps, but also breaking up clumps that already had formed.

Building upon that first generation of compounds, Lim and lab members Jung-Suk Choi and Joseph Braymer now report a second generation of compounds that are more stable in biological environments. The researchers tested one of those compounds, described in the PNAS paper, in homogenized brain tissue samples from Alzheimer's disease patients.

"We found that our compound is capable of disassembling the misfolded amyloid clumps to form smaller amyloid pieces, which might be 'cleansed' from the brain more easily, demonstrating a therapeutic application of our compound," said Lim, who has joint appointments in the Life Sciences Institute and the Department of Chemistry. In addition, preliminary tests show that the bi-functional small molecules have a strong potential to cross the blood-brain barrier, the barricade of cells that separates brain tissue from circulating blood, protecting the brain from harmful substances in the bloodstream.

"Crossing this barrier is essential for any treatment like this to be successful," Lim said.

Next steps include more intensive testing of the new compounds for diagnostic and therapeutic properties.

Lim and her team collaborated with Ayyalusamy Ramamoorthy, professor of chemistry and biophysics on this work, with funding from the U-M Horace H. Rackham School of Graduate Studies, the Alzheimer's Art Quilt Initiative, and the National Institutes of Health.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment.