Highest Freefall From Edge Of Space

Highest Freefall From Edge Of Space

  9:52:00 AM    Science Lover

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Felix Baumgartner Successfully Lands After Highest Freefall from Edge of Space

Austria's Felix Baumgartner earned his place in the history books on Sunday (Oct. 14, 2012) after overcoming concerns with the power for his visor heater that impaired his vision and nearly jeopardized the mission. Baumgartner reached an estimated speed of 1,342.8 km/h (Mach 1.24) jumping from the stratosphere, which when certified will make him the first man to break the speed of sound in freefall and set several other records* while delivering valuable data for future space exploration.

Screens at the mission control shows Pilot Felix Baumgartner of Austria jump during the final manned flight for Red Bull Stratos in Roswell, New Mexico, USA on October 14, 2012. (Credit: Jörg Mitter/Red Bull Content Pool)

After flying to an altitude of 39,045 meters (128,100 feet) in a helium-filled balloon, Felix Baumgartner completed Sunday morning a record breaking jump for the ages from the edge of space, exactly 65 years after Chuck Yeager first broke the sound barrier flying in an experimental rocket-powered airplane. The 43-year-old Austrian skydiving expert also broke two other world records (highest freefall, highest manned balloon flight), leaving the one for the longest freefall to project mentor Col. Joe Kittinger.

Baumgartner landed safely with his parachute in the desert of New Mexico after jumping out of his space capsule at 39,045 meters and plunging back towards earth, hitting a maximum of speed of 1,342.8 km/h through the near vacuum of the stratosphere before being slowed by the atmosphere later during his 4:20 minute long freefall. Countless millions of people around the world watched his ascent and jump live on television broadcasts and live stream on the Internet. At one point during his freefall Baumgartner appeared to spin rapidly, but he quickly re-gained control and moments later opened his parachute as members of the ground crew cheered and viewers around the world heaved a sigh of relief.

"It was an incredible up and down today, just like it's been with the whole project," a relieved Baumgartner said. "First we got off with a beautiful launch and then we had a bit of drama with a power supply issue to my visor. The exit was perfect but then I started spinning slowly. I thought I'd just spin a few times and that would be that, but then I started to speed up. It was really brutal at times. I thought for a few seconds that I'd lose consciousness. I didn't feel a sonic boom because I was so busy just trying to stabilize myself. We'll have to wait and see if we really broke the sound barrier. It was really a lot harder than I thought it was going to be."

Baumgartner and his team spent five years training and preparing for the mission that is designed to improve our scientific understanding of how the body copes with the extreme conditions at the edge of space.

Baumgartner had endured several weather-related delays before finally lifting off under bright blue skies and calm winds on Sunday morning. The Red Bull Stratos crew watching from Mission Control broke out into spontaneous applause when the balloon lifted off.

* The data on the records set by the jump are preliminary pending confirmation from the authorized governing bodies.

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Complex Logic Circuit from Bacterial Genes

Complex Logic Circuit from Bacterial Genes

  11:34:00 AM    Science Lover

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By force of habit we tend to assume computers are made of silicon, but there is actually no necessary connection between the machine and the material. All that an engineer needs to do to make a computer is to find a way to build logic gates -- the elementary building blocks of digital computers -- in whatever material is handy.

Just as electronic circuits are made from resistors, capacitors 
and transistors, biological circuits can be made from genes 
and regulatory proteins. Engineer Tae Seok Moon’s dream is 
to design modular “genetic parts” that can be used to build 
logic controllers inside microbes that will program them to 
make fuel, clean up pollutants, or kill infectious bacteria 
or cancerous cells. (Credit: © madarakis / Fotolia)

So logic gates could theoretically be made of pipes of water, channels for billiard balls or even mazes for soldier crabs.

By comparison Tae Seok Moon's ambition, which is to build logic gates out of genes, seems eminently practical. As a postdoctoral fellow in the lab of Christopher Voigt, PhD, a synthetic biologist at the Massachusetts Institute of Technology, he recently made the largest gene (or genetic) circuit yet reported.

Moon, PhD, now an assistant professor of energy, environmental and chemical engineering in the School of Engineering & Applied Science at Washington University in St. Louis is the lead author of an article describing the project in the Oct. 7 issue of Nature. Voigt is the senior author.

The tiny circuits constructed from these gene gates and others like them may one day be components of engineered cells that will monitor and respond to their environments.

The number of tasks they could undertake is limited only by evolution and human ingenuity. Janitor bacteria might clean up pollutants, chemical-engineer bacteria pump out biofuels and miniature infection-control bacteria might bustle about killing pathogens.

How to make an AND gate out of genes

The basis of modern computers is the logic gate, a device that makes simple comparisons between the bits, the 1s and 0s, in which computers encode information. Each logic gate has multiple inputs and one output. The output of the gate depends on the inputs and the operation the gate performs.

An AND gate, for example, turns on only if all of its inputs are on. An OR gate turns on if any of its inputs are on.

Suggestively, genes are turned on or off when a transcription factor binds to a region of DNA adjacent to the gene called a promotor.

To make an AND gate out of genes, however, Moon had to find a gene whose activation is controlled by at least two molecules, not one. So only if both molecule 1 AND molecule 2 are present will the gene be turned on and translated into protein.

Such a genetic circuit had been identified in Salmonella typhimurium, the bacterium that causes food poisoning. In this circuit, the transcription factor can bind to the promotor of a gene only if a molecule called a chaperone is present. This meant the genetic circuit could form the basis of a two-input AND gate.

The circuit Moon eventually built consisted of four sensors for four different molecules that fed into three two-input AND gates. If all four molecules were present, all three AND gates turned on and the last one produced a reporter protein that fluoresced red, so that the operation of the circuit could be easily monitored.

In the future, Moon says, a synthetic bacterium with this circuit might sense four different cancer indicators and, in the presence of all four, release a tumor-killing factor.

Crosstalk and timing faults

There are huge differences, of course, between the floppy molecules that embody biological logic gates and the diodes and transistors that embody electronic ones.

Engineers designing biological circuits worry a great deal about crosstalk, or interference. If a circuit is to work properly, the molecules that make up one gate cannot bind to molecules that are part of another gate.

This is much more of a problem in a biological circuit than in an electronic circuit because the interior of a cell is a kind of soup where molecules mingle freely.

To ensure that there wouldn't be crosstalk among his AND gates, Moon mined parts for his gates from three different strains of bacteria: Shigella flexneri and Pseudomonas aeruginosa, as well as Salmonella.

Although the parts from the three different strains were already quite dissimilar, he made them even more so by subjecting them to error-prone copying cycles and screening the copies for ones that were even less prone to crosstalk (but still functional).

Another problem Moon faced is that biological circuits, unlike electronic ones, don't have internal clocks that keep the bits moving through the logic gates in lockstep. If signals progress through layers of gates at different speeds, the output of the entire circuit may be wrong, a problem called a timing fault.

Experiments designed to detect such faults in the synthetic circuit showed that they didn't occur, probably because the chaperones for one layer of logic gates degrades before the transcription factors for the next layer are generated, and this forces a kind of rhythm on the circuit.

Hijacking a bacterium's controller

"We're not trying to build a computer out of biological logic gates," Moon says. "You can't build a computer this way. Instead we're trying to make controllers that will allow us to access all the things biological organisms do in simple, programmable ways."

"I see the cell as a system that consists of a sensor, a controller (the logic circuit), and an actuator," he says. "This paper covers work on the controller, but eventually the controller's output will drive an actuator, something that will do work on the cell's surroundings. "

An synthetic bacterium designed by a friend of Moon's at Nanyang Technological University in Singapore senses signaling molecules released by the pathogen Pseudomonas aeruginosa. When the molecules reach a high enough concentration, the bacterium generates a toxin and a protein that causes it to burst, releasing the toxin, and killing nearby P. aeruginosa.

"Silicon cannot do that," Moon says.

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'Invisibility': Key to Better Electronics?

'Invisibility': Key to Better Electronics?

  11:07:00 AM    Science Lover

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Visual 'Cloaking' Technology Enables More Efficient Transfer of Electrons

 A new approach that allows objects to become "invisible" has now been applied to an entirely different area: letting particles "hide" from passing electrons, which could lead to more efficient thermoelectric devices and new kinds of electronics.

Diagram shows the 'probability flux' of electrons, a 
representation of the paths of electrons as they pass through 
an 'invisible' nanoparticle. While the paths are bent as 
they enter the particle, they are subsequently bent back 
so that they re-emerge from the other side on the same 
trajectory they started with — just as if the particle 
wasn't there. (Credit: Image courtesy Bolin Liao et al.)

The concept -- developed by MIT graduate student Bolin Liao, former postdoc Mona Zebarjadi (now an assistant professor at Rutgers University), research scientist Keivan Esfarjani, and mechanical engineering professor Gang Chen -- is described in a paper in the journal Physical Review Letters.

Normally, electrons travel through a material in a way that is similar to the motion of electromagnetic waves, including light; their behavior can be described by wave equations. That led the MIT researchers to the idea of harnessing the cloaking mechanisms developed to shield objects from view -- but applying it to the movement of electrons, which is key to electronic and thermoelectric devices.

Previous work on cloaking objects from view has relied on so-called metamaterials made of artificial materials with unusual properties. The composite structures used for cloaking cause light beams to bend around an object and then meet on the other side, resuming their original path -- making the object appear invisible.

"We were inspired by this idea," says Chen, the Carl Richard Soderberg Professor of Power Engineering at MIT, who decided to study how it might apply to electrons instead of light. But in the new electron-cloaking material developed by Chen and his colleagues, the process is slightly different.

The MIT researchers modeled nanoparticles with a core of one material and a shell of another. But in this case, rather than bending around the object, the electrons do actually pass through the particles: Their paths are bent first one way, then back again, so they return to the same trajectory they began with.

In computer simulations, the concept appears to work, Liao says. Now, the team will try to build actual devices to see whether they perform as expected. "This was a first step, a theoretical proposal," Liao says. "We want to carry on further research on how to make some real devices out of this strategy."

While the initial concept was developed using particles embedded in a normal semiconductor substrate, the MIT researchers would like to see if the results can be replicated with other materials, such as two-dimensional sheets of graphene, which might offer interesting additional properties.

The MIT researchers' initial impetus was to optimize the materials used in thermoelectric devices, which produce an electrical current from a temperature gradient. Such devices require a combination of characteristics that are hard to obtain: high electrical conductivity (so the generated current can flow freely), but low thermal conductivity (to maintain a temperature gradient). But the two types of conductivity tend to coexist, so few materials offer these contradictory characteristics. The team's simulations show this electron-cloaking material could meet these requirements unusually well.

The simulations used particles a few nanometers in size, matching the wavelength of flowing electrons and improving the flow of electrons at particular energy levels by orders of magnitude compared to traditional doping strategies. This might lead to more efficient filters or sensors, the researchers say. As the components on computer chips get smaller, Chen says, "we have to come up with strategies to control electron transport," and this might be one useful approach.

The concept could also lead to a new kind of switches for electronic devices, Chen says. The switch could operate by toggling between transparent and opaque to electrons, thus turning a flow of them on and off. "We're really just at the beginning," he says. "We're not sure how far this is going to go yet, but there is some potential" for significant applications.

Xiang Zhang, a professor of mechanical engineering at the University of California at Berkeley who was not involved in this research, says "this is very exciting work" that expands the concept of cloaking to the domain of electrons. The authors, he says, "uncovered a very interesting approach that may be very useful to thermoelectric applications."

This research was funded by the U.S. Department of Energy (DOE) through MIT's Solid-State Solar-Thermal Energy Conversion center, a DOE Energy Frontier Research Center.

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Gravity Lenses: When Galaxies Eat Galaxies

Gravity Lenses: When Galaxies Eat Galaxies

  9:44:00 AM    Science Lover

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Using gravitational "lenses" in space, University of Utah astronomers discovered that the centers of the biggest galaxies are growing denser -- evidence of repeated collisions and mergers by massive galaxies with 100 billion stars.

This image, taken by the Hubble Space Telescope, shows 
a ring of light from a distant galaxy created when a closer 
galaxy in the  foreground – not shown in this processed 
image – acts as a “gravitational lens” to bend the light 
from the more distant galaxy into the ring of light, 
known as an Einstein ring. In a new study, University of 
Utah astronomer Adam Bolton and colleagues measured 
these Einstein rings to determine the mass of 79 lens 
galaxies that are massive elliptical galaxies, the largest 
kind of galaxy with 100 billion stars. The study found 
the centers of these big galaxies are getting denser over 
time, evidence of repeated collisions between massive 
galaxies. (Credit: Joel Brownstein, University of Utah, 
for NASA/ESA and the Sloan Digital Sky Survey)

"We found that during the last 6 billion years, the matter that makes up massive elliptical galaxies is getting more concentrated toward the centers of those galaxies. This is evidence that big galaxies are crashing into other big galaxies to make even bigger galaxies," says astronomer Adam Bolton, principal author of the new study.

"Most recent studies have indicated that these massive galaxies primarily grow by eating lots of smaller galaxies," he adds. "We're suggesting that major collisions between massive galaxies are just as important as those many small snacks."

The new study -- published recently in The Astrophysical Journal -- was conducted by Bolton's team from the Sloan Digital Sky Survey-III using the survey's 2.5-meter optical telescope at Apache Point, N.M., and the Earth-orbiting Hubble Space Telescope.

The telescopes were used to observe and analyze 79 "gravitational lenses," which are galaxies between Earth and more distant galaxies. A lens galaxy's gravity bends light from a more distant galaxy, creating a ring or partial ring of light around the lens galaxy.

The size of the ring was used to determine the mass of each lens galaxy, and the speed of stars was used to calculate the concentration of mass in each lens galaxy.

Bolton conducted the study with three other University of Utah astronomers -- postdoctoral researcher Joel Brownstein, graduate student Yiping Shu and undergraduate Ryan Arneson -- and with these members of the Sloan Digital Sky Survey: Christopher Kochanek, Ohio State University; David Schlegel, Lawrence Berkeley National Laboratory; Daniel Eisenstein, Harvard-Smithsonian Center for Astrophysics; David Wake, Yale University; Natalia Connolly, Hamilton College, Clinton, N.Y.; Claudia Maraston, University of Portsmouth, U.K.; and Benjamin Weaver, New York University.

Big Meals and Snacks for Massive Elliptical Galaxies

The new study deals with the biggest, most massive kind of galaxies, known as massive elliptical galaxies, which each contain about 100 billion stars. Counting unseen "dark matter," they contain the mass of 1 trillion stars like our sun.

"They are the end products of all the collisions and mergers of previous generations of galaxies," perhaps hundreds of collisions," Bolton says.

Despite recent evidence from other studies that massive elliptical galaxies grow by eating much smaller galaxies, Bolton's previous computer simulations showed that collisions between large galaxies are the only galaxy mergers that lead, over time, to increased mass density on the center of massive elliptical galaxies.

When a small galaxy merges with a larger one, the pattern is different. The smaller galaxy is ripped apart by gravity from the larger galaxy. Stars from the smaller galaxy remain near the outskirts -- not the center -- of the larger galaxy.

"But if you have two roughly comparable galaxies and they are on a collision course, each one penetrates more toward the center of the other, so more mass ends up in the center," Bolton says.

Other recent studies indicate stars are spread more widely within galaxies over time, supporting the idea that massive galaxies snack on much smaller ones.

"We're finding galaxies are getting more concentrated in their mass over time even though they are getting less concentrated in the light they emit," Bolton says.

He believes large galaxy collisions explain the growing mass concentration, while galaxies gobbling smaller galaxies explain more starlight away from galactic centers.

"Both processes are important to explain the overall picture," Bolton says. "The way the starlight evolves cannot be explained by the big collisions, so we really need both kinds of collisions, major and minor -- a few big ones and a lot of small ones."

The new study also suggests the collisions between large galaxies are "dry collisions" -- meaning the colliding galaxies lack large amounts of gas because most of the gas already has congealed to form stars -- and that the colliding galaxies hit each other "off axis" or with what Bolton calls "glancing blows" rather than head-on.

Sloan Meets Hubble: How the Study Was Conducted

The University of Utah joined the third phase of the Sloan Digital Sky Survey, known as SDSS-III, in 2008. It involves about 20 research institutions around the world. The project, which continues until 2014, is a major international effort to map the heavens as a way to search for giant planets in other solar systems, study the origin of galaxies and expansion of the universe, and probe the mysterious dark matter and dark energy that make up most of the universe.

Bolton says his new study was "almost gravy" that accompanied an SDSS-III project named BOSS, for Baryon Oscillation Spectrographic Survey. BOSS is measuring the history of the universe's expansion with unprecedented precision. That allows scientists to study the dark energy that accelerates expansion of the universe. The universe is believed to be made of only 4 percent regular matter, 24 percent unseen "dark matter" and 72 percent yet-unexplained dark energy.

During BOSS' study of galaxies, computer analysis of light spectra emitted by galaxies revealed dozens of gravitational lenses, which were discovered because the signatures of two different galaxies are lined up.

Bolton's new study involved 79 gravitational lenses observed by two surveys:

- The Sloan Survey and the Hubble Space Telescope collected images and emitted-light color spectra from relatively nearby, older galaxies -- including 57 gravitational lenses -- 1 billion to 3 billion years back into the cosmic past.

- Another survey identified 22 lenses among more distant, younger galaxies from 4 billion to 6 billion years in the past.

The rings of light around gravitational-lens galaxies are named "Einstein rings" because Albert Einstein predicted the effect, although he wasn't the first to do so.

"The more distant galaxy sends out diverging light rays, but those that pass near the closer galaxy get bent into converging light rays that appear to us as of a ring of light around the closer galaxy," says Bolton.

The greater the amount of matter in a lens galaxy, the bigger the ring. That seems counterintuitive, but the larger mass pulls with enough gravity to make the distant star's light bend so much that lines of light cross as seen by the observer, creating a bigger ring.

If there is more matter concentrated near the center of a galaxy, the faster stars will be seen moving toward or being slung away from the galactic center, Bolton says.

Alternative Theories

Bolton and colleagues acknowledge their observations might be explained by theories other than the idea that galaxies are getting denser in their centers over time:

- Gas that is collapsing to form stars can increase the concentration of mass in a galaxy. Bolton argues the stars in these galaxies are too old for that explanation to work.

- Gravity from the largest massive galaxies strips neighboring "satellite" galaxies of their outskirts, leaving more mass concentrated in the centers of the satellite galaxies. Bolton contends that process is not likely to produce the concentration of mass observed in the new study and explain how the extent of that central mass increases over time.

- The researchers merely detected the boundary in each galaxy between the star-dominated inner regions and the outer regions, which are dominated by unseen dark matter. Under this hypothesis, the appearance of growing galaxy mass concentration over time is due to a coincidence in researchers' measurement method, namely that they are measuring younger galaxies farther from their centers and measuring older galaxies closer to their centers, giving an illusion of growing mass concentration in galactic centers over time. Bolton says this measurement difference is too minor to explain the observed pattern of matter density within the lens galaxies.

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Nobel Prize in Chemistry 2012: Smart Receptors On Cell Surfaces

Nobel Prize in Chemistry 2012: Smart Receptors On Cell Surfaces

  9:32:00 AM    Science Lover

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The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2012 to Robert J. Lefkowitz Howard Hughes Medical Institute and Duke University Medical Center and Brian K. Kobilka Stanford University School of Medicine "for studies of G-protein-coupled receptors."

The seven-transmembrane α-helix structure of a 
G-protein-coupled receptor. (Credit: By Bensaccount at 
en.wikipedia [Public domain], from Wikimedia Commons)

Your body is a fine-tuned system of interactions between billions of cells. Each cell has tiny receptors that enable it to sense its environment, so it can adapt to new situtations. Robert Lefkowitz and Brian Kobilka are awarded the 2012 Nobel Prize in Chemistry for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled receptors.

For a long time, it remained a mystery how cells could sense their environment. Scientists knew that hormones such as adrenalin had powerful effects: increasing blood pressure and making the heart beat faster. They suspected that cell surfaces contained some kind of recipient for hormones. But what these receptors actually consisted of and how they worked remained obscured for most of the 20th Century.

Lefkowitz started to use radioactivity in 1968 in order to trace cells' receptors. He attached an iodine isotope to various hormones, and thanks to the radiation, he managed to unveil several receptors, among those a receptor for adrenalin: β-adrenergic receptor. His team of researchers extracted the receptor from its hiding place in the cell wall and gained an initial understanding of how it works.

The team achieved its next big step during the 1980s. The newly recruited Kobilka accepted the challenge to isolate the gene that codes for the β-adrenergic receptor from the gigantic human genome. His creative approach allowed him to attain his goal. When the researchers analyzed the gene, they discovered that the receptor was similar to one in the eye that captures light. They realized that there is a whole family of receptors that look alike and function in the same manner.

Today this family is referred to as G-protein-coupled receptors. About a thousand genes code for such receptors, for example, for light, flavour, odour, adrenalin, histamine, dopamine and serotonin. About half of all medications achieve their effect through G-protein-coupled receptors.

The studies by Lefkowitz and Kobilka are crucial for understanding how G-protein-coupled receptors function. Furthermore, in 2011, Kobilka achieved another break-through; he and his research team captured an image of the β-adrenergic receptor at the exact moment that it is activated by a hormone and sends a signal into the cell. This image is a molecular masterpiece -- the result of decades of research.

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